Journal article
Dietary Manganese Promotes Staphylococcal Infection of the Heart
Cell host & microbe, Vol.22(4), pp.531-542.e8
10/11/2017
DOI: 10.1016/j.chom.2017.08.009
PMCID: PMC5638708
PMID: 28943329
Abstract
Diet, and specifically dietary metals, can modify the risk of infection. However, the mechanisms by which manganese (Mn), a common dietary supplement, alters infection remain unexplored. We report that dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a leading cause of bacterial endocarditis. Mice fed a high Mn diet display alterations in Mn levels and localization within infected tissues, and S. aureus virulence and infection of the heart are enhanced. Although the canonical mammalian Mn-sequestering protein calprotectin surrounds staphylococcal heart abscesses, calprotectin is not released into the abscess nidus and does not limit Mn in this organ. Consequently, excess Mn is bioavailable to S. aureus in the heart. Bioavailable Mn is utilized by S. aureus to detoxify reactive oxygen species and protect against neutrophil killing, enhancing fitness within the heart. Therefore, a single dietary modification overwhelms vital host antimicrobial strategies, leading to fatal staphylococcal infection.
Details
- Title: Subtitle
- Dietary Manganese Promotes Staphylococcal Infection of the Heart
- Creators
- Lillian J. Juttukonda - Vanderbilt University Medical CenterEvelien T. M. Berends - New York UniversityJoseph P. Zackular - Vanderbilt University Medical CenterJessica L. Moore - Vanderbilt UniversityMatthew T. Stier - Vanderbilt University Medical CenterYaofang Zhang - Vanderbilt UniversityJonathan E. Schmitz - Vanderbilt University Medical CenterWilliam N. Beavers - Vanderbilt University Medical CenterChristiaan D. Wijers - Vanderbilt University Medical CenterBenjamin A. Gilston - Vanderbilt UniversityThomas E. Kehl-Fie - University of Illinois Urbana-ChampaignJames Atkinson - Vanderbilt University Medical CenterMary K. Washington - Vanderbilt University Medical CenterR. Stokes Peebles - Vanderbilt University Medical CenterWalter J. Chazin - Vanderbilt UniversityVictor J. Torres - New York UniversityRichard M. Caprioli - Vanderbilt UniversityEric P. Skaar - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Cell host & microbe, Vol.22(4), pp.531-542.e8
- Publisher
- Elsevier
- DOI
- 10.1016/j.chom.2017.08.009
- PMID
- 28943329
- PMCID
- PMC5638708
- ISSN
- 1931-3128
- eISSN
- 1934-6069
- Number of pages
- 20
- Grant note
- Rubicon fellowship from the Netherlands Organisation for Scientific Research P30DK058404 / Vanderbilt Digestive Disease Research Center (VDDRC) T32ES007028 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) INFB-024-13F / Veterans Affairs grant; US Department of Veterans Affairs T32 GM07347 / Public Health Service award from the National Institute of General Medical Studies T32DK007673 / NIH-NIDDK grant 15PRE25060007 / American Heart Association grant; American Heart Association T32GM008320 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) F32AI120553 / NIH-NIAID grant R01AI105129 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) AI101171; AI107233; AI069233; AI073843; 6P41 GM103391-06; AI099394; AI105129; AI103268; HHSN272201400019C / Public Health Service grants; United States Department of Health & Human Services; United States Public Health Service T32DK007673 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Defense Advanced Research Projects Agency (DARPA); United States Department of Defense
- Language
- English
- Date published
- 10/11/2017
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984618505602771
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