Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies

Xia Wang; Hongxia Chen; Yingying Ouyang; Jun Liu; Gang Zhao; Wei Bao; Maosheng Yan

doi:10.1186/s12916-014-0158-6

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Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies

Journal article

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Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies

Xia Wang, Hongxia Chen, Yingying Ouyang, Jun Liu, Gang Zhao, Wei Bao and Maosheng Yan

BMC medicine, Vol.12(1), 158

09/25/2014

DOI: 10.1186/s12916-014-0158-6

PMCID: PMC4199062

PMID: 25252963

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Abstract

Considerable controversy exists regarding the association between dietary calcium intake and risk of mortality from cardiovascular disease and all causes. Therefore, we performed a meta-analysis of prospective cohort studies to examine the controversy. We identified relevant studies by searching MEDLINE, Embase, and the Cochrane Library databases between 1 September 2013 and 30 December 2013. Reference lists of relevant articles were also reviewed. Observational prospective studies that reported relative risks and 95% confidence intervals for the association of calcium intake with cardiovascular and all-cause mortality were eligible. Study-specific relative risks were pooled using a random-effects model. In this meta-analysis, 11 prospective studies with 12 independent cohorts, involving 757,304 participants, were eligible. There was evidence of a non-linear association between dietary calcium intake and risk of mortality from cardiovascular disease (P for non-linearity <0.01) and all causes (P for non-linearity <0.01). A dose-response analysis showed a U-shaped relationship between dietary calcium intake and cardiovascular mortality. Intakes that were lower and higher than around 800 mg/day were gradually associated with a higher risk of cardiovascular mortality. For all-cause mortality, we also observed a threshold effect at intakes around 900 mg/day. The risk of all-cause mortality did not decrease further at intakes above 900 mg/day. This meta-analysis of prospective cohort studies suggests that dietary calcium intake is associated with cardiovascular mortality in a U-shaped manner and that high dietary calcium intake (>900 mg/day) is not associated with a decreased risk of all-cause mortality.

Prospective Studies

Risk Reduction Behavior

Calcium, Dietary - administration & dosage

Humans

Middle Aged

Risk Factors

Cardiovascular Diseases - mortality

Adult

Female

Male

Cohort Studies

Details

Title: Subtitle: Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies
Creators: Xia Wang
Hongxia Chen - Hubei University of Medicine
Yingying Ouyang
Jun Liu
Gang Zhao
Wei Bao - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. drwbao@hotmail.com
Maosheng Yan
Resource Type: Journal article
Publication Details: BMC medicine, Vol.12(1), 158
DOI: 10.1186/s12916-014-0158-6
PMID: 25252963
PMCID: PMC4199062
NLM abbreviation: BMC Med
ISSN: 1741-7015
eISSN: 1741-7015
Publisher: England
Language: English
Date published: 09/25/2014
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995045602771

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