Journal article
Dietary patterns and urinary phthalate exposure among postmenopausal women of the Women?s Health Initiative
Environmental research, Vol.216 (Part 3), 114727
01/01/2023
DOI: 10.1016/j.envres.2022.114727
PMCID: PMC10363918
PMID: 36356671
Abstract
Background: Phthalates are endocrine-disrupting chemicals linked to a higher risk of numerous chronic health outcomes. Diet is a primary source of exposure, but prior studies exploring associations between dietary patterns and phthalate exposure are limited. Objectives: We evaluated the associations between dietary patterns and urinary phthalate biomarkers among a subset of postmenopausal women participating in the Women's Health Initiative (WHI). Methods: We included WHI participants selected for a nested case-control study of phthalates and breast cancer (N = 1240). Dietary intake was measured via self-administered food frequency questionnaires at baseline and year-3. We used these data to calculate scores for alignment with the Dietary Approach to Stop Hypertension (DASH), alternative Mediterranean (aMed), and Dietary Inflammatory Index (DII) diets. We measured 13 phthalate metabolites and creatinine in 2-3 urine samples per participant collected over 3-years when all participants were cancer-free. We fit multivariable generalized estimating equation models to estimate the crosssectional associations. Results: DASH and aMed dietary scores were inversely associated with the sum of di(2-Ethylhexyl) phthalate (-6.48%, 95% CI -9.84, -3.00; -5.23%, 95% CI -8.73, -1.60) and DII score was positively associated (9.00%, 95% CI 5.04, 13.11). DASH and aMed scores were also inversely associated with mono benzyl phthalate and mono-3-carboxypropyl phthalate. DII scores were positively associated with mono benzyl phthalate and the sum of di-n-butyl phthalate. Discussion: Higher dietary alignment with DASH and aMed dietary patterns were significantly associated with lower concentrations of certain phthalate biomarkers, while an inflammatory diet pattern was associated with higher phthalate biomarker concentrations. These findings suggest that dietary patterns high in fruits, vegetables, and low-fat foods and low in processed foods may be useful in avoiding exposure to phthalates.
Details
- Title: Subtitle
- Dietary patterns and urinary phthalate exposure among postmenopausal women of the Women?s Health Initiative
- Creators
- Gabriela Vieyra - University of Massachusetts AmherstSusan E. Hankinson - University of Massachusetts AmherstYoussef Oulhote - University of Massachusetts AmherstLaura Vandenberg - Univ Massachusetts, Dept Environm Hlth Sci, Amherst, MA 01003 USALesley Tinker - Fred Hutch Cancer CenterJoAnn Mason - Brigham and Women's HospitalAladdin H. Shadyab - Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA USARobert Wallace - University of IowaChrisa Arcan - Virginia Commonwealth UniversityJ. C. Chen - University of Southern CaliforniaKatherine W. Reeves - University of Massachusetts Amherst
- Resource Type
- Journal article
- Publication Details
- Environmental research, Vol.216 (Part 3), 114727
- DOI
- 10.1016/j.envres.2022.114727
- PMID
- 36356671
- PMCID
- PMC10363918
- NLM abbreviation
- Environ Res
- ISSN
- 0013-9351
- eISSN
- 1096-0953
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- R01ES024731 / National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) 75N92021D00001; 75N92021D00002; 75N92021D00003; 75N92021D00004; 75N92021D00005 / National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364551002771
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