Dietary patterns are associated with disease risk among participants in the Women's Health Initiative Observational Study

Linda Van Horn; Lu Tian; Marian L Neuhouser; Barbara V Howard; Charles B Eaton; Linda Snetselaar; Nirupa R Matthan; Alice H Lichtenstein

doi:10.3945/jn.111.145375

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Dietary patterns are associated with disease risk among participants in the Women's Health Initiative Observational Study

Journal article

Open access

Peer reviewed

Dietary patterns are associated with disease risk among participants in the Women's Health Initiative Observational Study

Linda Van Horn, Lu Tian, Marian L Neuhouser, Barbara V Howard, Charles B Eaton, Linda Snetselaar, Nirupa R Matthan and Alice H Lichtenstein

The Journal of nutrition, Vol.142(2), pp.284-291

02/2012

DOI: 10.3945/jn.111.145375

PMCID: PMC3260060

PMID: 22190026

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Abstract

Coronary heart disease (CHD) is the leading cause of death in women. A nested case-control study tested whether dietary patterns predicted CHD events among 1224 participants in the Women's Health Initiative-Observational Study (WHI-OS) with centrally confirmed CHD, fatal or nonfatal myocardial infarct compared to 1224 WHI-OS controls matched for age, enrollment date, race/ethnicity, and absence of CHD at baseline or follow-up. The first six principal components explained >75% of variation in dietary intakes and K-mean analysis based on these six components produced three clusters. Diet cluster 1 was rich in carbohydrate, vegetable protein, fiber, dietary vitamin K, folate, carotenoids, α-linolenic acid [18:3(n-3)], linoleic acid [18:2(n-6)], and supplemental calcium and vitamin D. Diet cluster 2 was rich in total and animal protein, arachidonic acid [20:4(n-6)], DHA [22:6(n-3)], vitamin D, and calcium. Diet cluster 3 was rich in energy, total fat, and trans fatty acids (all P < 0.01). Conditional logistic regression analysis demonstrated diet cluster 1 was associated with lower CHD risk than diet cluster 2 (reference group) adjusted for smoking, education, and physical activity [OR = 0.79 (95% CI = 0.64, 0.99); P = 0.038]. This difference was not significant after adjustment for BMI and systolic blood pressure. Diet cluster 3 was associated with higher CHD risk than diet cluster 2 [OR = 1.28 (95% CI = 1.04, 1.57); P = 0.019], but this difference did not remain significant after adjustment for smoking, education, and physical activity. Within this WHI-OS cohort, distinct dietary patterns may be associated with subsequent CHD outcomes.

Aging

Diet - adverse effects

Humans

Middle Aged

Risk Factors

Coronary Disease - etiology

Coronary Disease - epidemiology

Feeding Behavior

Logistic Models

Case-Control Studies

Ethnic Groups

Women's Health - statistics & numerical data

Female

Aged

Odds Ratio

Principal Component Analysis

Cluster Analysis

Details

Title: Subtitle: Dietary patterns are associated with disease risk among participants in the Women's Health Initiative Observational Study
Creators: Linda Van Horn - Department of Preventive Medicine, Northwestern University, Chicago, IL, USA. lvanhorn@northwestern.edu
Lu Tian
Marian L Neuhouser
Barbara V Howard
Charles B Eaton
Linda Snetselaar
Nirupa R Matthan
Alice H Lichtenstein
Resource Type: Journal article
Publication Details: The Journal of nutrition, Vol.142(2), pp.284-291
DOI: 10.3945/jn.111.145375
PMID: 22190026
PMCID: PMC3260060
NLM abbreviation: J Nutr
ISSN: 0022-3166
eISSN: 1541-6100
Publisher: United States
Grant note: P30 CA015704 / NCI NIH HHS N01WH32122 / WHI NIH HHS N01WH32100-2 / WHI NIH HHS N01WH32118-32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32108-9 / WHI NIH HHS N01WH24152 / WHI NIH HHS HHSN26800764317C / PHS HHS N01WH42129-32 / WHI NIH HHS N01WH42107-26 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH32111-13 / WHI NIH HHS N01WH32105-6 / WHI NIH HHS
Language: English
Date published: 02/2012
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983996600802771

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