Journal article
Dietary polyamine intake and colorectal cancer risk in postmenopausal women
The American journal of clinical nutrition, Vol.102(2), pp.411-419
08/01/2015
DOI: 10.3945/ajcn.114.103895
PMCID: PMC4515861
PMID: 26135350
Abstract
Background: Putrescine, spermidine, and spermine (i.e., polyamines) are small cationic amines synthesized by cells or acquired from the diet or gut bacteria. Polyamines are required for both normal and colorectal cancer (CRC) cell growth.
Objective: We investigated the association between dietary polyamines and risk of CRC incidence and mortality.
Design: The study was a prospective analysis in 87,602 postmenopausal women in the Women's Health Initiative Observational Study. Multivariate Cox regression was used to calculate HRs and 95% CIs.
Results: Total dietary polyamine intake (mean +/- SD: 289.2 +/- 127.4 mu mol/d) was not positively associated with CRC in fully adjusted models. Instead, intake >= 179.67 mu mol/d was associated with reduced risk of CRC [HR (95% CI): 0.82 (0.68, 1.00), 0.81 (0.66, 0.99), 0.91 (0.74, 1.12), and 0.80 (0.62, 1.02) for quintiles 2-5, respectively, compared with quintile 1]. Reduced risk was not significant across all quintiles. Polyamines were not significantly associated with CRC-specific mortality in fully adjusted models. When stratified by risk factors for CRC, only body mass index (BMI) and fiber intake significantly modified the association between polyamine intake and CRC. In women with BMI (in kg/m(2)) <= 25 or fiber consumption above the median, polyamine intake was associated with significantly lower risk of CRC.
Conclusions: No positive association between dietary Polyamines and CRC or CRC-specific mortality risk in women was observed. Instead, a protective effect of dietary polyamines was suggested in women with some CRC risk-lowering behaviors in particular. These results are consistent with emerging evidence that exogenous polyamines may be beneficial in colon health and warrant additional study.
Details
- Title: Subtitle
- Dietary polyamine intake and colorectal cancer risk in postmenopausal women
- Creators
- Ashley J. Vargas - University of ArizonaErin L. Ashbeck - University of ArizonaBetsy C. Wertheim - University of ArizonaRobert B. Wallace - University of IowaMarian L. Neuhouser - Fred Hutch Cancer CenterCynthia A. Thomson - University of ArizonaPatricia A. Thompson - University of Arizona
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.102(2), pp.411-419
- DOI
- 10.3945/ajcn.114.103895
- PMID
- 26135350
- PMCID
- PMC4515861
- NLM abbreviation
- Am J Clin Nutr
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Publisher
- AMER SOC NUTRITION-ASN
- Number of pages
- 9
- Grant note
- P30CA015704 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) HHSN268201100046C; HHSN268201100001C; HHSN268201100002C; HHSN268201100003C; HHSN268201100004C; HHSN271201100004C / US Department of Health and Human Services National Heart, Lung, and Blood Institute, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P30ES005605 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Language
- English
- Date published
- 08/01/2015
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363582202771
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