Journal article
Dietary sodium effects on renin and angiotensinogen gene expression in preweanling WKY and SHR
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.271(5), pp.R1439-R1446
11/01/1996
DOI: 10.1152/ajpregu.1996.271.5.R1439
PMID: 8945984
Abstract
The influence of altered dietary sodium on angiotensinogen and renin gene expression was examined in young normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Artificial rearing was used to increase or decrease dietary sodium intake during the preweanling period. In normally reared control animals, renal renin and liver angiotensinogen mRNA decreased between 6 and 30 postnatal days of age. In contrast, in the central nervous system, angiotensinogen mRNA increased between 6 and 30 days of age, and renin mRNA remained stable. Dietary sodium manipulation between postnatal days (PD) 6 and 18 significantly influenced renal renin gene expression, with low-sodium diet increasing renin mRNA on PD12 and PD18 and high-sodium diet decreasing renin mRNA on PD18. Liver angiotensinogen mRNA decreased for animals on either diet on PD12 and PD18. Brain angiotensinogen and renin mRNA were not affected by dietary sodium levels. There were no strain-related differences in the response to high and low dietary sodium. These results demonstrate that 1) the peripheral and central renin-angiotensin systems do not have a common ontogenetic pattern of development, 2) they are independently regulated in response to dietary sodium variations, and 3) young WKY and SHR share very similar ontogenetic patterns of angiotensinogen and renin gene expression.
Details
- Title: Subtitle
- Dietary sodium effects on renin and angiotensinogen gene expression in preweanling WKY and SHR
- Creators
- Robert F Kirby - Department of Psychology, University of Iowa, Iowa City 52242,USAWilliam V Page - Department of Psychology, University of Iowa, Iowa City 52242,USAAlan Kim Johnson - Department of Psychology, University of Iowa, Iowa City 52242,USAJean E Robillard - Department of Psychology, University of Iowa, Iowa City 52242,USA
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.271(5), pp.R1439-R1446
- DOI
- 10.1152/ajpregu.1996.271.5.R1439
- PMID
- 8945984
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 11/01/1996
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Neuroscience and Pharmacology; Medicine Administration; University College Courses; Health and Human Physiology
- Record Identifier
- 9984213270802771
Metrics
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