Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats

Howard P Glauert; Zijing Lu; Amita Kumar; R Petruta Bunaciu; Sandip Patel; Job C Tharappel; Divinia N Stemm; Hans-Joachim Lehmler; Eun Y Lee; Larry W Robertson; Brett T Spear

doi:10.1093/jn/135.2.283

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Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats

Journal article

Open access

Peer reviewed

Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats

Howard P Glauert, Zijing Lu, Amita Kumar, R Petruta Bunaciu, Sandip Patel, Job C Tharappel, Divinia N Stemm, Hans-Joachim Lehmler, Eun Y Lee, Larry W Robertson, …

The Journal of nutrition, Vol.135(2), pp.283-286

02/2005

DOI: 10.1093/jn/135.2.283

PMID: 15671227

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Abstract

In this study, the effect of dietary vitamin E on the hepatic tumor-promoting activity of PCB-77 and PCB-153 in female Sprague-Dawley rats (175-200 g) was investigated. One week after diethylnitrosamine injection, rats were fed purified diets containing 10, 50, or 250 mg/kg vitamin E in the form of alpha-tocopheryl acetate. Starting 1 wk later, we injected rats i.p. with vehicle (corn oil) or PCB-77 or PCB-153 (300 mumol/kg) every 14 d for 4 injections. All rats were killed 10 d after the last PCB injection. The number and volume of placental glutathione S-transferase (PGST)-positive foci were increased by PCB-77 but not by PCB-153. Vitamin E did not affect the induction of PGST-positive foci. PCB-77, but not PCB-153, increased hepatic NF-kappaB activity. In conclusion, dietary vitamin E supplementation does not protect against the induction of altered hepatic focal lesions by PCBs.

Liver Neoplasms - prevention & control

Liver - metabolism

Liver Neoplasms - chemically induced

Rats

NF-kappa B - metabolism

Rats, Sprague-Dawley

Animals

Diet

Liver - drug effects

Polychlorinated Biphenyls - toxicity

Vitamin E - administration & dosage

Female

Vitamin E - pharmacology

Details

Title: Subtitle: Dietary vitamin E does not inhibit the promotion of liver carcinogenesis by polychlorinated biphenyls in rats
Creators: Howard P Glauert - Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506, USA. hglauert@uky.edu
Zijing Lu
Amita Kumar
R Petruta Bunaciu
Sandip Patel
Job C Tharappel
Divinia N Stemm
Hans-Joachim Lehmler
Eun Y Lee
Larry W Robertson
Brett T Spear
Resource Type: Journal article
Publication Details: The Journal of nutrition, Vol.135(2), pp.283-286
DOI: 10.1093/jn/135.2.283
PMID: 15671227
NLM abbreviation: J Nutr
ISSN: 0022-3166
eISSN: 1541-6100
Publisher: United States
Grant note: P42 ES013661 / NIEHS NIH HHS ES 07380 / NIEHS NIH HHS
Language: English
Date published: 02/2005
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute
Record Identifier: 9984001087302771

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