Journal article
Diet‐microbiome‐immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria
European journal of immunology, Vol.53(11), 2250236
11/2023
DOI: 10.1002/eji.202250236
PMCID: PMC11606726
PMID: 37673213
Appears in UI Libraries Support Open Access
Abstract
Abstract Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. Although HLA genes have emerged as the strongest genetic factor linked to MS, consensus on the environmental risk factors is lacking. Recently, the gut microbiota has garnered increasing attention as a potential environmental factor in MS, as mounting evidence suggests that individuals with MS exhibit microbial dysbiosis (changes in the gut microbiome). Thus, there has been a strong emphasis on understanding the role of the gut microbiome in the pathobiology of MS, specifically, factors regulating the gut microbiota and the mechanism(s) through which gut microbes may contribute to MS. Among all factors, diet has emerged to have the strongest influence on the composition and function of gut microbiota. As MS patients lack gut bacteria capable of metabolizing dietary phytoestrogen, we will specifically discuss the role of a phytoestrogen diet and phytoestrogen metabolizing gut bacteria in the pathobiology of MS. A better understanding of these mechanisms will help to harness the enormous potential of the gut microbiota as potential therapeutics to treat MS and other autoimmune diseases.
Details
- Title: Subtitle
- Diet‐microbiome‐immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria
- Creators
- Peter C. Lehman - University of IowaSudeep Ghimire - University of IowaJeffrey D. Price - University of Nebraska–LincolnAmanda E. Ramer-Tait - University of Nebraska–LincolnAshutosh K. Mangalam - University of Iowa
- Resource Type
- Journal article
- Publication Details
- European journal of immunology, Vol.53(11), 2250236
- DOI
- 10.1002/eji.202250236
- PMID
- 37673213
- PMCID
- PMC11606726
- NLM abbreviation
- Eur J Immunol
- ISSN
- 0014-2980
- eISSN
- 1521-4141
- Publisher
- Wiley
- Grant note
- National Institutes of Health/NIAID 1R01AI137075 (AKM). Grant Number: 1I01CX002212 University of Iowa Environmental Health Sciences Research Center. Grant Number: NIH P30 ES005605 Gift from P. Heppelmann and M. Wacek NIH: Interdisciplinary Immunology Postdoctoral Training Program. Grant Number: T32AI007260
- Language
- English
- Electronic publication date
- 09/06/2023
- Date published
- 11/2023
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984463077902771
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