Diet‐microbiome‐immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria

Peter C. Lehman; Sudeep Ghimire; Jeffrey D. Price; Amanda E. Ramer-Tait; Ashutosh K. Mangalam

doi:10.1002/eji.202250236

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Diet‐microbiome‐immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria

Journal article

Open access

Peer reviewed

Diet‐microbiome‐immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria

Peter C. Lehman, Sudeep Ghimire, Jeffrey D. Price, Amanda E. Ramer-Tait and Ashutosh K. Mangalam

European journal of immunology, Vol.53(11), 2250236

11/2023

DOI: 10.1002/eji.202250236

PMCID: PMC11606726

PMID: 37673213

Appears in UI Libraries Support Open Access

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Abstract

Abstract Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. Although HLA genes have emerged as the strongest genetic factor linked to MS, consensus on the environmental risk factors is lacking. Recently, the gut microbiota has garnered increasing attention as a potential environmental factor in MS, as mounting evidence suggests that individuals with MS exhibit microbial dysbiosis (changes in the gut microbiome). Thus, there has been a strong emphasis on understanding the role of the gut microbiome in the pathobiology of MS, specifically, factors regulating the gut microbiota and the mechanism(s) through which gut microbes may contribute to MS. Among all factors, diet has emerged to have the strongest influence on the composition and function of gut microbiota. As MS patients lack gut bacteria capable of metabolizing dietary phytoestrogen, we will specifically discuss the role of a phytoestrogen diet and phytoestrogen metabolizing gut bacteria in the pathobiology of MS. A better understanding of these mechanisms will help to harness the enormous potential of the gut microbiota as potential therapeutics to treat MS and other autoimmune diseases.

Diet

Microbial dysbiosis

Microbiota

Master of Science (MS)

Phytoestrogen

UIOWA OA Agreement

Details

Title: Subtitle: Diet‐microbiome‐immune interplay in multiple sclerosis: Understanding the impact of phytoestrogen metabolizing gut bacteria
Creators: Peter C. Lehman - University of Iowa
Sudeep Ghimire - University of Iowa
Jeffrey D. Price - University of Nebraska–Lincoln
Amanda E. Ramer-Tait - University of Nebraska–Lincoln
Ashutosh K. Mangalam - University of Iowa
Resource Type: Journal article
Publication Details: European journal of immunology, Vol.53(11), 2250236
DOI: 10.1002/eji.202250236
PMID: 37673213
PMCID: PMC11606726
NLM abbreviation: Eur J Immunol
ISSN: 0014-2980
eISSN: 1521-4141
Publisher: Wiley
Grant note: National Institutes of Health/NIAID 1R01AI137075 (AKM). Grant Number: 1I01CX002212 University of Iowa Environmental Health Sciences Research Center. Grant Number: NIH P30 ES005605 Gift from P. Heppelmann and M. Wacek NIH: Interdisciplinary Immunology Postdoctoral Training Program. Grant Number: T32AI007260
Language: English
Electronic publication date: 09/06/2023
Date published: 11/2023
Academic Unit: Pathology; Iowa Neuroscience Institute
Record Identifier: 9984463077902771

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