Differences Among Veterans With Chronic Overlapping Pain Conditions and Other Chronic Pain: Baseline Results From the LAMP Pain Management Trial

Jenna L Adamowicz; Alexis Grant; Collin Calvert; Daniel Elchert; Katherine Hadlandsmyth; Mary A Driscoll; Stephanie L Taylor; Kelli Allen; Brent C Taylor; Diana J Burgess

doi:10.1002/ejp.70125

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Differences Among Veterans With Chronic Overlapping Pain Conditions and Other Chronic Pain: Baseline Results From the LAMP Pain Management Trial

Journal article

Peer reviewed

Differences Among Veterans With Chronic Overlapping Pain Conditions and Other Chronic Pain: Baseline Results From the LAMP Pain Management Trial

Jenna L Adamowicz, Alexis Grant, Collin Calvert, Daniel Elchert, Katherine Hadlandsmyth, Mary A Driscoll, Stephanie L Taylor, Kelli Allen, Brent C Taylor and Diana J Burgess

European journal of pain, Vol.29(9), e70125

10/2025

DOI: 10.1002/ejp.70125

PMID: 40948198

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Abstract

Chronic overlapping pain conditions (COPCs) are a constellation of disorders posited to share an underlying pain mechanism (nociplastic pain). Unfortunately, individuals with COPCs are under-represented in clinical research. The current study aimed to determine COPC prevalence among participants enrolled in a pragmatic clinical trial and compare those with COPCs to those with non-COPCs across several domains. Learning to Apply Mindfulness to Pain (LAMP) study baseline data of veterans with chronic pain (N = 811) were utilised. COPC diagnoses were determined using ICD-10 codes within electronic health records. Group differences across pain and functioning-related domains were compared with and without adjustment for age and gender. Among participants with COPCs (54%), most were diagnosed with only one COPC (74%). Chronic lower back pain (71%) and migraine (28%) were the most common. Participants with COPCs were younger and more likely to be female relative to those with non-COPCs. The COPC subset was also more likely to be diagnosed with PTSD, depressive disorders and sleep disorders (p < 0.05). Those with COPCs also reported greater pain severity and interference, more impaired health-related quality of life, greater pain catastrophising and lower pain self-efficacy than participants without COPCs (p < 0.05). COPCs were common among a sample of veterans in a pragmatic clinical trial. Several baseline differences emerged indicating veterans with COPCs experience greater mental health concerns and endorse distinct pain characteristics and pain mediators. Future research is needed to further characterise this recently defined and under-represented group. Individuals with COPCs are medically complex, yet are understudied and underrepresented within pain trials research. COPCs, which predominantly impact women, are also understudied within U.S. veterans. Our findings highlight how veterans with COPCs are participating in clinical research even when interventions are not tailored to their unique characteristics. Our work also contributes to a nuanced understanding of this disease burden and is among the first to describe differences among veterans with COPCs and veterans with chronic pain but without COPCs.

Adult

Aged

Chronic Pain - epidemiology

Chronic Pain - psychology

Chronic Pain - therapy

Female

Humans

Male

Middle Aged

Mindfulness

Pain Management - methods

Veterans - psychology

Details

Title: Subtitle: Differences Among Veterans With Chronic Overlapping Pain Conditions and Other Chronic Pain: Baseline Results From the LAMP Pain Management Trial
Creators: Jenna L Adamowicz - Yale University
Alexis Grant - VA Connecticut Healthcare System
Collin Calvert - Minneapolis VA Health Care System
Daniel Elchert - Minneapolis VA Health Care System
Katherine Hadlandsmyth - Iowa City VA Health Care System
Mary A Driscoll - Yale University
Stephanie L Taylor - VA Greater Los Angeles Healthcare System
Kelli Allen - Durham VA Health Care System
Brent C Taylor - Minneapolis VA Health Care System
Diana J Burgess - Minneapolis VA Health Care System
Resource Type: Journal article
Publication Details: European journal of pain, Vol.29(9), e70125
DOI: 10.1002/ejp.70125
PMID: 40948198
NLM abbreviation: Eur J Pain
ISSN: 1090-3801
eISSN: 1532-2149
Publisher: WILEY
Grant note: Assistant Secretary of Defence for Health Affairs - Department of Defence, through the Pain Management Collaboratory-Pragmatic Clinical Trials Demonstration Projects: W81XWH-18-2-0003 National Center for Complementary and Integrative Health (NCCIH): U24AT009769 Office of Disease Prevention (ODP)Office of Behavioural and Social Sciences Research (OBSSR)National Institute on Alcohol Abuse and Alcoholism (NIAAA)Minneapolis VA Health Care SystemDurham VA Health Care SystemVA Greater Los Angeles Healthcare System
The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. This work was supported by the Assistant Secretary of Defence for Health Affairs endorsed by the Department of Defence, through the Pain Management Collaboratory-Pragmatic Clinical Trials Demonstration Projects under Award No. W81XWH-18-2-0003. The publication and project were made possible by Grant Number U24AT009769 from the National Center for Complementary and Integrative Health (NCCIH), the Office of Disease Prevention (ODP), the Office of Behavioural and Social Sciences Research (OBSSR) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). This material is the result of work supported with resources at the Minneapolis VA Health Care System, Durham VA Health Care System and VA Greater Los Angeles Healthcare System. This material is a product of the Pain Management Collaboratory. For more information about the Collaboratory, visit https://painmanagementcollaboratory.org/.
Language: English
Date published: 10/2025
Academic Unit: Psychological and Brain Sciences; Nursing; Anesthesia
Record Identifier: 9984964232702771

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