Journal article
Differences between Burkitt's lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations
Cancer research (Chicago, Ill.), Vol.55(21), pp.5012-5018
11/01/1995
PMID: 7585544
Abstract
Burkitt's lymphomas (BLs) and mouse plasmacytomas (MPs) are characterized by chromosomal translocations juxtaposing the c-myc oncogene to one of the immunoglobulin loci. Here we describe illegitimate recombinations and the DNA sequence at the junction between c-myc and immunoglobulin heavy chain (IgH) regions in these B-cell lineage tumors. In 15 BLs and in 29 MPs, recombination products were amplified by PCR and sequenced. Molecular analysis of the IgH/c-myc junctions revealed the following characteristics: (a) rearrangements in BLs represent nearly reciprocal exchanges between c-myc and IgH switch sequences, whereas in MPs, several hundred bp of c-myc may be duplicated or deleted; (b) short homologies of up to 5 bp between immunoglobulin and c-myc sequences can be found at most junction sites in both tumors; and (c) pentameric sequences typically found in switch regions and V(D)J recognition motifs also occur frequently at the sites of recombination in c-myc.
Details
- Title: Subtitle
- Differences between Burkitt's lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations
- Creators
- Jürgen R Müller - Laboratory of Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USASiegfried JanzMichael Potter
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.55(21), pp.5012-5018
- PMID
- 7585544
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Language
- English
- Date published
- 11/01/1995
- Academic Unit
- Pathology
- Record Identifier
- 9984083843402771
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