Journal article
Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin
Neurology, Vol.40(9), pp.1420-1426
1990
DOI: 10.1212/wnl.40.9.1420
PMID: 2392229
Abstract
We performed interictal [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in 17 patients with well-defined unilateral anterior mesial temporal epileptogenic foci as determined by EEG procedures. Sixteen of these patients subsequently underwent surgical resection of the epileptogenic focus. We measured local cerebral metabolic rates for glucose in mesial and lateral temporal structures and compared them with metabolic rates for analogous regions in 16 healthy normal volunteers and the contralateral hemisphere of the epileptic patients. We found relative hypometabolism ipsilateral to the seizure focus more frequently and to a greater degree in the lateral than in the mesial temporal cortex. Since the physiologic abnormalities involved mesial temporal structures, this observation suggests that functional pathways exist between mesial and lateral temporal cortex normally and that these pathways are altered in epilepsy of mesial temporal origin. Hypometabolism did not correlate well with histologic abnormalities in the surgical specimens. © 1990 American Academy of Neurology.
Details
- Title: Subtitle
- Differences between lateral and mesial temporal metabolism interictally in epilepsy of mesial temporal origin
- Creators
- J. C Sackellares - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United StatesG. J Siegel - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United StatesB. W ABOU-KHALIL - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United StatesT. W Hood - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United StatesS Gilman - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United StatesP. E Mckeever - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United StatesR. D Hichwa - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United StatesG. D Hutchins - Univ. Michigan school medicine, dep. neurology, Ann Arbor MI 48109-0316, United States
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.40(9), pp.1420-1426
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1212/wnl.40.9.1420
- PMID
- 2392229
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 1990
- Academic Unit
- Radiology; Research Administration; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984213291302771
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