Differences in Aggressive Behavior and DNA Copy Number Variants Between BALB/cJ and BALB/cByJ Substrains

Lady Velez; Greta Sokoloff; Klaus A Miczek; Abraham A Palmer; Stephanie C Dulawa

doi:10.1007/s10519-009-9325-5

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Differences in Aggressive Behavior and DNA Copy Number Variants Between BALB/cJ and BALB/cByJ Substrains

Journal article

Peer reviewed

Differences in Aggressive Behavior and DNA Copy Number Variants Between BALB/cJ and BALB/cByJ Substrains

Lady Velez, Greta Sokoloff, Klaus A Miczek, Abraham A Palmer and Stephanie C Dulawa

Behavior genetics, Vol.40(2), pp.201-210

12/23/2009

DOI: 10.1007/s10519-009-9325-5

PMCID: PMC3722062

PMID: 20033273

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Abstract

Some BALB/c substrains exhibit different levels of aggression. We compared aggression levels between male BALB/cJ and BALB/cByJ substrains using the resident intruder paradigm. These substrains were also assessed in other tests of emotionality and information processing including the open field, forced swim, fear conditioning, and prepulse inhibition tests. We also evaluated single nucleotide polymorphisms (SNPs) previously reported between these BALB/c substrains. Finally, we compared BALB/cJ and BALB/cByJ mice for genomic deletions or duplications, collectively termed copy number variants (CNVs), to identify candidate genes that might underlie the observed behavioral differences. BALB/cJ mice showed substantially higher aggression levels than BALB/cByJ mice; however, only minor differences in other behaviors were observed. None of the previously reported SNPs were verified. Eleven CNV regions were identified between the two BALB/c substrains. Our findings identify a robust difference in aggressive behavior between BALB/cJ and BALB/cByJ substrains, which could be the result of the identified CNVs.

Aggression

BALB

CNV

Resident intruder

Substrain

Details

Title: Subtitle: Differences in Aggressive Behavior and DNA Copy Number Variants Between BALB/cJ and BALB/cByJ Substrains
Creators: Lady Velez - University of Chicago
Greta Sokoloff - University of Chicago
Klaus A Miczek - Tufts University
Abraham A Palmer - University of Chicago
Stephanie C Dulawa - University of Chicago
Resource Type: Journal article
Publication Details: Behavior genetics, Vol.40(2), pp.201-210
DOI: 10.1007/s10519-009-9325-5
PMID: 20033273
PMCID: PMC3722062
NLM abbreviation: Behav Genet
ISSN: 0001-8244
eISSN: 1573-3297
Grant note: R01 AA013983 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA
Language: English
Date published: 12/23/2009
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984256931102771

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