Journal article
Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow-up: Relation to Dysglycemia
Diabetes (New York, N.Y.), Vol.74(8), pp.1417-1426
08/01/2025
DOI: 10.2337/db24-0684
PMCID: PMC12278787
PMID: 40455934
Abstract
Type 1 diabetes has detrimental effects in white matter in young children. We performed a longitudinal study using brain MRI (diffusion tensor imaging) and cognitive assessments in 4- to 9-year-old children, control participants without diabetes (n = 71) and with type 1 diabetes (n = 143), plus continuous glucose monitoring, to assess changes at four time points as children grow over 6-8 years. White matter myelination and fiber integrity were assessed using axial diffusivity, which was decreased in the diabetes versus control group, less so during puberty, and fractional anisotropy was reciprocally related to hyperglycemia. Data suggest continued negative impact of chronic hyperglycemia in the developing brain.
Details
- Title: Subtitle
- Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow-up: Relation to Dysglycemia
- Creators
- Nelly Mauras - Nemours Children's Health SystemQianheng Ma - Stanford UniversityStuart A Weinzimer - Yale UniversityNeil H White - Washington University in St. LouisEva Tsalikian - University of IowaBruce Buckingham - Stanford UniversityLarry A Fox - Nemours Children's Health SystemWilliam Tamborlane - Yale UniversityAna Maria Arbelaez - Washington University in St. LouisMichael Tansey - University of IowaTandy Aye - Stanford UniversityAllison Cato - Nemours Children's Health SystemTamara Hershey - Washington University in St. LouisKim Englert - Nemours Children's Health SystemMatthew Marzelli - Stanford UniversityBooil Jo - Stanford UniversityAllan Reiss - Stanford UniversityDiabetes Research in Children Network (DirecNet)
- Resource Type
- Journal article
- Publication Details
- Diabetes (New York, N.Y.), Vol.74(8), pp.1417-1426
- DOI
- 10.2337/db24-0684
- PMID
- 40455934
- PMCID
- PMC12278787
- NLM abbreviation
- Diabetes
- ISSN
- 1939-327X
- eISSN
- 1939-327X
- Publisher
- AMER DIABETES ASSOC
- Grant note
- MH123443 / National Institute of Child Health and Human Development U01-HD-41908 / National Institute of Child Health and Human Development U01-HD-56526 / Washington University in St. Louis Medtronic U01-HD-41906 / National Institute of Child Health and Human Development U01-HD-41906 / Washington University in St. Louis UL1-TR-001085 / Washington University in St. Louis UL1-TR-001085 / National Institute of Child Health and Human Development U01-HD-41915 / National Institute of Child Health and Human Development R01-HD-078463 / National Institute of Child Health and Human Development
- Language
- English
- Electronic publication date
- 06/02/2025
- Date published
- 08/01/2025
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984826342602771
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