Journal article
Differences in the Clinical Outcome of Ischemic and Nonischemic Cardiomyopathy in Heart Failure With Concomitant Opioid Use Disorder
Current problems in cardiology, Vol.48(5), p.101609
05/01/2023
DOI: 10.1016/j.cpcardiol.2023.101609
PMID: 36690309
Abstract
Heart Failure (HF) and Opioid Use Disor-der (OUD) independently have significant impact on patients and the United States (US) health system. In the setting of the opioid epidemic, research on the effects of OUD on cardiovascular diseases is rapidly evolving. However, no study exists on differential out-comes of ischemic cardiomyopathy (ICM) and noni-schemic cardiomyopathy (NICM) in patients with HF with OUD. We performed a retrospective, observa-tional cohort study using National Inpatient Sample (NIS) 2018-2020 databases. Patients aged 18 years and above with diagnoses of HF with concomitant OUD were included. Patients were further classified into ICM and NICM. Primary outcome of interest was dif-ferences in all-cause in-hospital mortality. Secondary outcome was incidence of cardiogenic shock. We iden-tified 99,810 hospitalizations that met inclusion crite-ria, ICM accounted for 27%. Mean age for ICM was higher compared to NICM (63 years vs 56 years, P < 0.01). Compared to NICM, patients with ICM had higher cardiovascular disease risk factors and comor-bidities; type 2 diabetes mellitus (46.3 % vs 30.1%, P < 0.01), atrial fibrillation/flutter (33.5% vs 29.9%, P < 0.01), hyperlipidemia (52.5% vs 28.9%, P < 0.01), and Charlson comorbidity index >5 was 46.7% versus 29.7%, P < 0.01. After controlling for covariates and potential confounders, we observed higher odds of all -cause in-hospital mortality in patients with NICM (aOR = 1.36; 95% CI:1.03-1.78, P = 0.02). There was no statistical significant difference in incidence of car-diogenic shock between ICM and NICM (aOR = 0.86;95% CI 0.70-1.07, P = 0.18). In patients with HF with concomitant OUD, we found a 36% increase in odds of all-cause in-hospital mortality in patients with NICM compared to ICM despite being younger in age with less comorbidities. There was no difference in odds of in-hospital cardiogenic shock in this study population. This study contributes to the dis-cussion of OUD and cardiovascular diseases which is rapidly developing and requires further prospective studies. (Curr Probl Cardiol 2023;48:101609.)
Details
- Title: Subtitle
- Differences in the Clinical Outcome of Ischemic and Nonischemic Cardiomyopathy in Heart Failure With Concomitant Opioid Use Disorder
- Creators
- John Gharbin - Howard University HospitalAdwoa Winful - Doctors HospitalMubariz Ahmed Hassan - Howard University HospitalSiddharth Bajaj - Howard University HospitalYashvardhan Batta - Howard UniversityPamela Alebna - Saint Barnabas Medical CenterSuchellis Rhodd - Howard University HospitalMohammed Taha - Howard UniversityUrooj Fatima - Howard UniversityPrafulla Mehrotra - Howard University
- Resource Type
- Journal article
- Publication Details
- Current problems in cardiology, Vol.48(5), p.101609
- DOI
- 10.1016/j.cpcardiol.2023.101609
- PMID
- 36690309
- NLM abbreviation
- Curr Probl Cardiol
- ISSN
- 0146-2806
- eISSN
- 1535-6280
- Publisher
- Elsevier
- Number of pages
- 13
- Language
- English
- Date published
- 05/01/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984848508202771
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