Journal article
Differences in the Regulation of Vascular Resistance in Guinea Pigs with Right and Left Heart Failure
Circulation research, Vol.41(1), pp.85-93
07/1977
DOI: 10.1161/01.RES.41.1.85
PMID: 140773
Abstract
SUMMARY We investigated neurogenic, non-neurogenic, and structural contributions to vascular resistance in hindquarters in five groups of guinea pigs after heart failure produced by (1) constriction of the pulmonary artery (RHF), (2) constriction of the ascending aorta (LHFA), and (3) constriction of the descending thoracic aorta (LHFD); (4) after left ventricular hypertrophy produced by mild constriction of the ascending aorta (LVH); and (5) after sham surgery. Pressure-flow curves were used to assess vascular resistance in the isolated, perfused hindquarters. In RHF and LHFA, vascular resistance tended to increase and for different reasons. In the LHFA group, sympathectomy produced the greatest vasodilation. Therefore, neurogenic influences predominated. The high neurogenic tone may have been related to reduced arterial pulse pressure (P < 0.05) and reflexes arising in arterial baroreceptors. In contrast, the LHFD group had increased arterial pressure and pulse pressure (P < 0.05) and normal neurogenic vasoconstriction. However, non-neurogenic vasoconstriction was increased probably as a result of increased vascular responsiveness to constrictor stimuli. In the RHF group, papaverine produced the greatest vasodilation (P < 0.05). Therefore, non-neurogenic influences predominated. This was attributed to both increased vascular responsiveness and to altered humoral stimuli. Similar maximal vasodilation indicated that structural factors contributed equally to vascular resistance in all the groups. These results indicate differences in the regulation of vascular resistance in anesthetized, guinea pig models of right and left heart failure.
Details
- Title: Subtitle
- Differences in the Regulation of Vascular Resistance in Guinea Pigs with Right and Left Heart Failure
- Creators
- PHILLIP SCHMID - Cardiovascular Division, Department of Internal Medicine, the Cardiovascular Center, University of Iowa College of Medicine, and the Veterans Administration Hospital, Iowa City, IowaHOWARD MAYERALLYN MARKDONALD HEISTADFRANCOIS ABBOUD
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.41(1), pp.85-93
- Publisher
- American Heart Association, Inc
- DOI
- 10.1161/01.RES.41.1.85
- PMID
- 140773
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 07/1977
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025321702771
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