Journal article
Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
Molecular psychiatry, Vol.29(10), pp.3086-3096
10/2024
DOI: 10.1038/s41380-024-02563-z
PMCID: PMC11449795
PMID: 38671214
Abstract
Formal thought disorder (FTD) is a clinical key factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, the relationship between FTD symptom dimensions and patterns of regional brain volume loss in schizophrenia remains to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles by enrolling a large multi-site cohort acquired by the ENIGMA Schizophrenia Working Group (752 schizophrenia patients and 1256 controls), to unravel the neuroanatomy of FTD in schizophrenia and using virtual histology tools on implicated brain regions to investigate the cellular basis. Based on the findings of previous clinical and neuroimaging studies, we decided to separately explore positive, negative and total formal thought disorder. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but positive and negative FTD demonstrated a dissociation: negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD also showed associations with microglial cell types. These results provide an important step towards linking FTD to brain structural changes and their cellular underpinnings, providing an avenue for a better mechanistic understanding of this syndrome.
Details
- Title: Subtitle
- Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset
- Creators
- Rachel J. Sharkey - University of IowaChelsea Bacon - University of IowaZeru Peterson - University of IowaKelly Rootes-Murdy - Georgia State UniversityRaymond Salvador - Hospital Mare de Déu de la MercèEdith Pomarol-Clotet - CIBERSAM ISCIII, FIDMAG Germanes Hosp Res Fdn, Barcelona, SpainAndriana Karuk - Hospital Mare de Déu de la MercèPhilipp Homan - Psychiat Univ Hosp Zurich PUK, Dept Psychiat Psychotherapy & Psychosomat, CH-8008 Zurich, SwitzerlandEllen Ji - Psychiat Univ Hosp Zurich PUK, Dept Psychiat Psychotherapy & Psychosomat, CH-8008 Zurich, SwitzerlandWolfgang Omlor - Psychiat Univ Hosp Zurich PUK, Dept Psychiat Psychotherapy & Psychosomat, CH-8008 Zurich, SwitzerlandStephanie Homan - Psychiat Univ Hosp Zurich PUK, Dept Psychiat Psychotherapy & Psychosomat, CH-8008 Zurich, SwitzerlandFoivos Georgiadis - Psychiat Univ Hosp Zurich PUK, Dept Psychiat Psychotherapy & Psychosomat, CH-8008 Zurich, SwitzerlandStefan Kaiser - University Hospital of GenevaMatthias Kirschner - University Hospital of GenevaStefan Ehrlich - Technische Universität DresdenUdo Dannlowski - University of MünsterDominik Grotegerd - University of MünsterJanik Goltermann - University of MünsterSusanne Meinert - University of MünsterTilo Kircher - Philipps University of MarburgFrederike Stein - Philipps University of MarburgKatharina Brosch - Philipps University of MarburgAxel Krug - University of BonnIgor Nenadic - Philipps University of MarburgKang Sim - Institute of Mental HealthGianfranco Spalletta - IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, ItalyNerisa Banaj - Fondazione Santa LuciaScott R. Sponheim - University of MinnesotaCaroline Demro - University of MinnesotaIan S. Ramsay - University of MinnesotaMargaret King - Mind Research NetworkYann Quide - UNSW SydneyMelissa Jane Green - UNSW SydneyDana Nguyen - University of California, IrvineAdrian Preda - University of California, IrvineVince Calhoun - Center for Translational Research in Neuroimaging and Data ScienceJessica Turner - The Ohio State UniversityTheo van Erp - University of California, IrvineThomas Nickl-Jockschat - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.29(10), pp.3086-3096
- DOI
- 10.1038/s41380-024-02563-z
- PMID
- 38671214
- PMCID
- PMC11449795
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- Instituto de Salud Carlos III; Spanish Government
- Language
- English
- Electronic publication date
- 04/26/2024
- Date published
- 10/2024
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984623023702771
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