Journal article
Different 212 Pb Generators and Its Radiation Safety Concerning 220 Rn (Thoron) Emanation
Toxics (Basel), Vol.13(6), 462
05/30/2025
DOI: 10.3390/toxics13060462
PMCID: PMC12197070
PMID: 40559935
Abstract
(1) Background: As the demand for 212Pb for clinical theranostics rises, empirical studies that examine the radiation safety implications of different 224Ra sources are needed to facilitate discussions with local authorities for the translation of 203/212Pb theranostics routine clinical practice.
(2) Methods: Environmental 220Rn (Thoron) emanation was detected by a RAD7 detector in the vicinity of respective 212Pb sources and additional alpha-dosimeters to detect 220Rn during generator elution, radiosynthesis, and quality control. Personnel gamma exposure was measured using whole-body and ring dosimeters. Generators included those based on wet-chemical-process- and emanation-based technology. (3) Results: During generator handling, varying levels of 220Rn were observed in the vicinity of generators. An additional monthly whole-body dose must be considered when handling different sources of 212Pb generators, and this depends upon local shielding and the handling approaches toward use of the technology
(4) Conclusions: 224Ra in any form (including radionuclide generators) should always be handled within a fume hood to keep potential contamination and exposure to personnel as low as reasonably achievable. Following standard practices of radiation safety, generators of 212Pb can be used safely for theranostic applications.
Details
- Title: Subtitle
- Different 212 Pb Generators and Its Radiation Safety Concerning 220 Rn (Thoron) Emanation
- Creators
- Marc Pretze - University Hospital Carl Gustav CarusHolger Hartmann - University Hospital Carl Gustav CarusCharlotte Duchemin - European Organization for Nuclear ResearchThierry Stora - European Organization for Nuclear ResearchMuhammad Inzamam - European Organization for Nuclear ResearchDavid Kästner - University Hospital Carl Gustav CarusEdwin A Sagastume - Perspective Therapeutics, Coralville, IA 52241, USAMichael K Schultz - University of IowaJörg Kotzerke - University Hospital Carl Gustav CarusRalph A Bundschuh - University Hospital Carl Gustav CarusRobert Freudenberg - University Hospital Carl Gustav Carus
- Resource Type
- Journal article
- Publication Details
- Toxics (Basel), Vol.13(6), 462
- DOI
- 10.3390/toxics13060462
- PMID
- 40559935
- PMCID
- PMC12197070
- NLM abbreviation
- Toxics
- eISSN
- 2305-6304
- Publisher
- MDPI
- Grant note
- GA 101008571 / European Union's Horizon 2020 research and innovation programme as a user project of PRIS-MAP - The European medical radionuclides programme
- Language
- English
- Date published
- 05/30/2025
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984833491102771
Metrics
6 Record Views