Different Adaptations in AMPA Receptor Transmission in the Nucleus Accumbens after Short vs Long Access Cocaine Self-Administration Regimens

Anthony Purgianto; Andrew F Scheyer; Jessica A Loweth; Kerstin A Ford; Kuei Y Tseng; Marina E Wolf

doi:10.1038/npp.2013.78

Back

Different Adaptations in AMPA Receptor Transmission in the Nucleus Accumbens after Short vs Long Access Cocaine Self-Administration Regimens

Journal article

Open access

Peer reviewed

Different Adaptations in AMPA Receptor Transmission in the Nucleus Accumbens after Short vs Long Access Cocaine Self-Administration Regimens

Anthony Purgianto, Andrew F Scheyer, Jessica A Loweth, Kerstin A Ford, Kuei Y Tseng and Marina E Wolf

Neuropsychopharmacology (New York, N.Y.), Vol.38(9), pp.1789-1797

05/08/2013

DOI: 10.1038/npp.2013.78

PMCID: PMC3717554

PMID: 23546386

Files and links (1)

url

https://doi.org/10.1038/npp.2013.78View

Published (Version of record) Open Access

Abstract

Ca 2+ -permeable AMPA receptors (CP-AMPARs) accumulate in the nucleus accumbens (NAc) after ∼1 month of withdrawal from a long-access cocaine self-administration regimen (6 h/d, 10d). This is functionally significant because CP-AMPARs mediate the ‘incubated' cue-induced cocaine craving produced by this regimen. Our present goal was to determine if other commonly employed cocaine self-administration regimens also elicit CP-AMPAR accumulation. We compared four regimens, named according to whether sessions were short-access (ShA, 2 h) or long-access (LgA, 6 h) and the total number of sessions: LgA/10d (already shown to elicit CP-AMPAR accumulation), ShA/11d, ShA/20-24d, and LgA/20-24d. In the latter regimens, rats began with 10 days of ShA and then entered a differential phase (10–14 days) in which ShA sessions either continued or switched to LgA. Controls self-administered saline. After >40 days of withdrawal, whole-cell patch-clamp recordings were performed in NAc core medium spiny neurons to assess the contribution of CP-AMPAR transmission, based on the magnitude of synaptic suppression elicited by bath application of the selective CP-AMPAR antagonist naspm (100 μM). Naspm produced a non-significant (∼10%) attenuation of electrically evoked local excitatory postsynaptic current in the saline and ShA groups. By contrast, a significant naspm-induced synaptic attenuation (25–30%) was observed in both the LgA groups. Further analyses indicate that this emergence of CP-AMPAR transmission in the LgA groups is associated with increased baseline responsiveness of MSN to excitatory drive. Together with data on cocaine infusions in each group, our results show that CP-AMPAR accumulation and enhanced glutamate transmission is associated with longer sessions (6 h), rather than the number of sessions or cocaine infusions.

addiction & substance abuse

AMPA receptors

animal models

cocaine

glutamate

nucleus accumbens

Original

plasticity

self-administration

Details

Title: Subtitle: Different Adaptations in AMPA Receptor Transmission in the Nucleus Accumbens after Short vs Long Access Cocaine Self-Administration Regimens
Creators: Anthony Purgianto - Rosalind Franklin University of Medicine and Science
Andrew F Scheyer - Rosalind Franklin University of Medicine and Science
Jessica A Loweth - Rosalind Franklin University of Medicine and Science
Kerstin A Ford - Rosalind Franklin University of Medicine and Science
Kuei Y Tseng - Rosalind Franklin University of Medicine and Science
Marina E Wolf - Rosalind Franklin University of Medicine and Science
Resource Type: Journal article
Publication Details: Neuropsychopharmacology (New York, N.Y.), Vol.38(9), pp.1789-1797
DOI: 10.1038/npp.2013.78
PMID: 23546386
PMCID: PMC3717554
NLM abbreviation: Neuropsychopharmacology
ISSN: 0893-133X
eISSN: 1740-634X
Publisher: Nature Publishing Group
Alternative title: Cocaine regimen determines AMPAR plasticity
Language: English
Date published: 05/08/2013
Academic Unit: Psychiatry
Record Identifier: 9984296258102771

Metrics

24 Record Views

67 Times Cited - Web of Science