Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects

Masanari Kuwabara; Remi Kuwabara; Koichiro Niwa; Ichiro Hisatome; Gerard Smits; Carlos A Roncal-Jimenez; Paul S MacLean; Joseph M Yracheta; Minoru Ohno; Miguel A Lanaspa; Richard J Johnson; Diana I Jalal

doi:10.3390/nu10081011

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Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects

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Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects

Masanari Kuwabara, Remi Kuwabara, Koichiro Niwa, Ichiro Hisatome, Gerard Smits, Carlos A Roncal-Jimenez, Paul S MacLean, Joseph M Yracheta, Minoru Ohno, Miguel A Lanaspa, …

Nutrients, Vol.10(8), p.1011

08/03/2018

DOI: 10.3390/nu10081011

PMCID: PMC6115805

PMID: 30081468

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Abstract

Obesity is a risk factor for hypertension, diabetes mellitus (DM), dyslipidemia, and hyperuricemia. Here, we evaluated whether the same body mass index (BMI) for the U.S. population conferred similar metabolic risk in Japan. This was a cross-sectional analysis involving 90,047 Japanese adults (18⁻85 years) from St. Luke's International Hospital, Tokyo, Japan and 14,734 adults from National Health and Nutrition Examination Survey (NHANES) collected in the U.S. We compared the prevalence of hypertension, DM, dyslipidemia, and hyperuricemia according to BMI in Japan and the U.S. The prevalence of hypertension, DM, and dyslipidemia were significantly higher in the U.S. than Japan, whereas the prevalence of hyperuricemia did not differ between countries. Higher BMI was an independent risk factor for hypertension, DM, dyslipidemia, and hyperuricemia both in Japan and in the U.S. after adjusting for age, sex, smoking and drinking habits, chronic kidney disease, and other cardiovascular risk factors. The BMI cut-off above which the prevalence of these cardio-metabolic risk factors increased was significantly higher in the U.S. than in Japan (27 vs. 23 kg/m² for hypertension, 29 vs. 23 kg/m² for DM, 26 vs. 22 kg/m² for dyslipidemia, and 27 vs. 23 kg/m² for hyperuricemia). Higher BMI is associated with an increased prevalence of hypertension, DM, dyslipidemia, and hyperuricemia both in Japan and U.S. The BMI cut-off above which the prevalence of cardio-metabolic risk factors increases is significantly lower in Japan than the U.S., suggesting that the same definition of overweight/obesity may not be similarly applicable in both countries.

Blood Pressure

Diabetes Mellitus - blood

Japan - epidemiology

United States - epidemiology

Prevalence

Nutrition Surveys

Humans

Middle Aged

Male

Young Adult

Dyslipidemias - blood

Aged, 80 and over

Adult

Female

Obesity - diagnosis

Retrospective Studies

Uric Acid - blood

Diabetes Mellitus - diagnosis

Hypertension - epidemiology

Hypertension - diagnosis

Dyslipidemias - diagnosis

Body Mass Index

Blood Glucose - analysis

Cross-Sectional Studies

Risk Assessment

Hyperuricemia - diagnosis

Risk Factors

Obesity - physiopathology

Biomarkers - blood

Hypertension - physiopathology

Hyperuricemia - blood

Dyslipidemias - epidemiology

Diabetes Mellitus - epidemiology

Obesity - epidemiology

Adolescent

Aged

Hyperuricemia - epidemiology

Details

Title: Subtitle: Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects
Creators: Masanari Kuwabara - Cardiovascular Center, St. Luke's International Hospital, Tokyo 104-8560, Japan. kuwamasa728@gmail.com
Remi Kuwabara - Department of Pediatrics, Nihon University School of Medicine, Tokyo 173-8610, Japan. remi.kuwabara@gmail.com
Koichiro Niwa - Cardiovascular Center, St. Luke's International Hospital, Tokyo 104-8560, Japan. kniwa@aol.com
Ichiro Hisatome - Division of Regenerative Medicine and Therapeutics, Department of Regenerative Medicine and Genomic Function, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, Yonago, Tottori 683-8503, Japan. hisatome@med.tottori-u.ac.jp
Gerard Smits - Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. smits.gerard.j@gmail.com
Carlos A Roncal-Jimenez - Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. Carlos.Roncal@ucdenver.edu
Paul S MacLean - Division of Endocrinology, Metabolism and Diabetes, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. Paul.MacLean@ucdenver.edu
Joseph M Yracheta - Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA. jmy5@uw.edu
Minoru Ohno - Department of Cardiology, Toranomon Hospital, Tokyo 105-8470, Japan. minotky@gmail.com
Miguel A Lanaspa - Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. Miguel.LanaspaGarcia@ucdenver.edu
Richard J Johnson - Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. Richard.Johnson@ucdenver.edu
Diana I Jalal - Department of Medicine, University of Iowa, Iowa, IA 52242, USA. diana-jalal@uiowa.edu
Resource Type: Journal article
Publication Details: Nutrients, Vol.10(8), p.1011
DOI: 10.3390/nu10081011
PMID: 30081468
PMCID: PMC6115805
NLM abbreviation: Nutrients
ISSN: 2072-6643
eISSN: 2072-6643
Grant note: R01 DK108859 / NIDDK NIH HHS P30 DK048520 / NIDDK NIH HHS
Language: English
Date published: 08/03/2018
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094502102771

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