Journal article
Different clinical and magnetic resonance imaging features between Charcot–Marie–Tooth disease type 1A and 2A
Neuromuscular disorders : NMD, Vol.18(8), pp.610-618
2008
DOI: 10.1016/j.nmd.2008.05.012
PMID: 18602827
Abstract
Charcot–Marie–Tooth disease type 1A (CMT1A) is the more frequent cause of demyelinating CMT, and CMT2A is the most common cause of axonal CMT. We conducted a magnetic resonance imaging (MRI) study on 39 CMT1A and 21 CMT2A patients to compare their neuroimaging patterns and correlate with clinical features. CMT1A patients showed selective fatty infiltration with a preference for anterior and lateral compartment muscles, whereas CMT2A patients showed a preference for superficial posterior compartment muscles. Early-onset CMT2A patients showed more severe leg fatty atrophy than late-onset CMT2A patients. In late-onset CMT2A, soleus muscle was the earliest, and most severely affected than the other leg muscles. Selective involvement of intrinsic foot muscles is a characteristic pattern of minimal CMT1A and CMT2A. Our MRI study demonstrates different patterns of fatty infiltration involving superficial posterior compartment muscles in CMT2A (partial T-type), and peroneal nerve innervated muscles in CMT1A (P-type).
Details
- Title: Subtitle
- Different clinical and magnetic resonance imaging features between Charcot–Marie–Tooth disease type 1A and 2A
- Creators
- K.W Chung - Department of Biological Science, Kongju National University, Gongju, Republic of KoreaB.C Suh - Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaM.E Shy - Department of Neurology, and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USAS.Y Cho - Department of Neurology, and Ewha Medical Research Center, Ewha Womans University School of Medicine, Mokdong Hospital, 911-1 Mokdong Yangcheon-ku, Seoul 158-710, Republic of KoreaJ.H Yoo - Department of Radiology, and Ewha Medical Research Center, Ewha Womans University School of Medicine, Mokdong Hospital, 911-1 Mokdong Yangcheon-ku, Seoul 158-710, Republic of KoreaS.W Park - Department of Biological Science, Kongju National University, Gongju, Republic of KoreaH Moon - Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaK.D Park - Department of Neurology, and Ewha Medical Research Center, Ewha Womans University School of Medicine, Mokdong Hospital, 911-1 Mokdong Yangcheon-ku, Seoul 158-710, Republic of KoreaK.G Choi - Department of Neurology, and Ewha Medical Research Center, Ewha Womans University School of Medicine, Mokdong Hospital, 911-1 Mokdong Yangcheon-ku, Seoul 158-710, Republic of KoreaS Kim - Department of Radiology, Hanyang University College of Medicine, Seoul, Republic of KoreaS.B Kim - Department of Neurology, Kyung Hee University East-West Neo Medical Center, Seoul, Republic of KoreaD.S Shim - Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of KoreaS.M Kim - Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of KoreaI.N Sunwoo - Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of KoreaB.O Choi - Department of Neurology, and Ewha Medical Research Center, Ewha Womans University School of Medicine, Mokdong Hospital, 911-1 Mokdong Yangcheon-ku, Seoul 158-710, Republic of Korea
- Resource Type
- Journal article
- Publication Details
- Neuromuscular disorders : NMD, Vol.18(8), pp.610-618
- DOI
- 10.1016/j.nmd.2008.05.012
- PMID
- 18602827
- NLM abbreviation
- Neuromuscul Disord
- ISSN
- 0960-8966
- eISSN
- 1873-2364
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2008
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020790702771
Metrics
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