Journal article
Different fate of antibodies to surface IgM and IgD in germinal centre cell-associated lymphomas
Scandinavian journal of immunology, Vol.19(5), pp.447-455
05/1984
DOI: 10.1111/j.1365-3083.1984.tb00953.x
PMID: 6427920
Abstract
In all of four human germinal centre cell-associated B lymphomas carrying sIgM + sIgD F(ab')2 fragments of rabbit antibodies to human mu-chain were accumulated intracellularly, whereas the accumulation of antibodies to delta-chain was considerably less abundant. The accumulation of antibodies to light chain was intermediate between antibodies to mu- and delta-chain. These results could be explained by the following observations: (i) the difference in the level of reexpression of sIgM and sIgD and (ii) the discovery that antibodies to delta-chain bound to reexpressed sIgD were degraded at a higher rate than those bound to primary sIgD and at a higher rate than antibodies to mu-chain, whether bound to primary or reexpressed sIgM.
Details
- Title: Subtitle
- Different fate of antibodies to surface IgM and IgD in germinal centre cell-associated lymphomas
- Creators
- E RuudK BeiskeA DrackH B SteenT Godal
- Resource Type
- Journal article
- Publication Details
- Scandinavian journal of immunology, Vol.19(5), pp.447-455
- Publisher
- England
- DOI
- 10.1111/j.1365-3083.1984.tb00953.x
- PMID
- 6427920
- ISSN
- 0300-9475
- eISSN
- 1365-3083
- Language
- English
- Date published
- 05/1984
- Academic Unit
- Stead Family Department of Pediatrics; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979911002771
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