Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice

Stewart Thompson; Steven F Stasheff; Jasmine Hernandez; Erik Nylen; Jade S East; Randy H Kardon; Lawrence H Pinto; Robert F Mullins; Edwin M Stone

doi:10.1167/iovs.10-6146

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Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice

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Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice

Stewart Thompson, Steven F Stasheff, Jasmine Hernandez, Erik Nylen, Jade S East, Randy H Kardon, Lawrence H Pinto, Robert F Mullins and Edwin M Stone

Investigative ophthalmology & visual science, Vol.52(1), pp.618-623

02/01/2011

DOI: 10.1167/iovs.10-6146

PMCID: PMC3053302

PMID: 20847113

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Abstract

Detection of light in the eye contributes both to spatial awareness (form vision) and to responses that acclimate an animal to gross changes in light (irradiance detection). This dual role means that eye disease that disrupts form vision can also adversely affect physiology and behavioral state. The purpose of this study was to investigate how inner retinal circuitry mediating rod-cone photoreceptor input contributes to functionally distinct irradiance responses and whether that might account for phenotypic diversity in retinal disease. The sensitivity of the pupillary light reflex and negative masking (activity suppression by light) was measured in wild-type mice with intact inner retinal circuitry, Nob4 mice that lack ON-bipolar cell function, and rd1 mice that lack rods and cones and, therefore, have no input to ON or OFF bipolar cells. An expected increase in sensitivity to negative masking with loss of photoreceptor input in rd1 was duplicated in Nob4 mice. In contrast, sensitivity of the pupillary light reflex was more severely reduced in rd1 than in Nob4 mice. Absence of ON-bipolar cell-mediated rod-cone input can fully explain the phenotype of outer retina degeneration for negative masking but not for the pupillary light reflex. Therefore, inner retinal pathways mediating rod-cone input are different for negative masking and the pupillary light reflex.

Retinal Cone Photoreceptor Cells - radiation effects

Motor Activity - physiology

Retinal Ganglion Cells - physiology

Reflex, Pupillary - radiation effects

Retinal Rod Photoreceptor Cells - radiation effects

Mice, Inbred C57BL

Retinal Cone Photoreceptor Cells - physiology

Male

Retinal Degeneration - physiopathology

Behavior, Animal

Reflex, Pupillary - physiology

Vision, Ocular - physiology

Animals

Retinal Bipolar Cells - physiology

Mice, Mutant Strains

Light

Retinal Rod Photoreceptor Cells - physiology

Visual Perception

Mice

Details

Title: Subtitle: Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice
Creators: Stewart Thompson - Howard Hughes Medical Institute, Universityof Iowa, Iowa City, Iowa 52242, USA
Steven F Stasheff
Jasmine Hernandez
Erik Nylen
Jade S East
Randy H Kardon
Lawrence H Pinto
Robert F Mullins
Edwin M Stone
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.52(1), pp.618-623
DOI: 10.1167/iovs.10-6146
PMID: 20847113
PMCID: PMC3053302
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Grant note: Howard Hughes Medical Institute
Language: English
Date published: 02/01/2011
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983980092602771

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