Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes

Raheleh Roudi; Alireza Korourian; Ahmad Shariftabrizi; Zahra Madjd

doi:10.3109/07357907.2015.1034869

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Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes

Journal article

Peer reviewed

Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes

Raheleh Roudi, Alireza Korourian, Ahmad Shariftabrizi and Zahra Madjd

Cancer investigation, Vol.33(7), pp.294-302

2015

DOI: 10.3109/07357907.2015.1034869

PMID: 26046383

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Abstract

Cancer stem cells (CSCs) are hypothesized to be the main culprit of lung cancer progression. Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group of lung cancer patients was evaluated. ALDH1 and CD133 had higher expression levels in the NSCLC compared to the SCLC. Over-expression of both ALDH1 and CD133 markers was exclusively found in SCC and ADC. Low level of ALDH1 expression was strongly correlated with poor differentiation in ADC cases. Thus, ALDH1(high)/CD133(high) phenotype can be considered as a CSC marker in some lung cancer subtypes.

AC133 Antigen

Adenocarcinoma - metabolism

Adenocarcinoma - pathology

Adult

Aged

Aged, 80 and over

Antigens, CD - metabolism

Biomarkers, Tumor - metabolism

Carcinoma, Non-Small-Cell Lung - metabolism

Carcinoma, Non-Small-Cell Lung - pathology

Female

Glycoproteins - metabolism

Humans

Isoenzymes - metabolism

Lung Neoplasms - metabolism

Lung Neoplasms - pathology

Male

Middle Aged

Neoplastic Stem Cells - metabolism

Neoplastic Stem Cells - pathology

Peptides - metabolism

Retinal Dehydrogenase - metabolism

Tissue Array Analysis

Details

Title: Subtitle: Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes
Creators: Raheleh Roudi - Iran University of Medical Sciences
Alireza Korourian - Iran University of Medical Sciences
Ahmad Shariftabrizi - University at Buffalo, State University of New York
Zahra Madjd
Resource Type: Journal article
Publication Details: Cancer investigation, Vol.33(7), pp.294-302
DOI: 10.3109/07357907.2015.1034869
PMID: 26046383
ISSN: 0735-7907
eISSN: 1532-4192
Language: English
Date published: 2015
Academic Unit: Radiology
Record Identifier: 9984318689102771

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