Journal article
Differential Resting-State Connectivity Patterns of the Right Anterior and Posterior Dorsolateral Prefrontal Cortices (DLPFC) in Schizophrenia
Frontiers in psychiatry, Vol.9(MAY), pp.211-211
05/28/2018
DOI: 10.3389/fpsyt.2018.00211
PMID: 29892234
Abstract
In schizophrenia (SCZ), dysfunction of the dorsolateral prefrontal cortex (DLPFC) has been linked to the deficits in executive functions and attention. It has been suggested that, instead of considering the right DLPFC as a cohesive functional entity, it can be divided into two parts (anterior and posterior) based on its whole-brain connectivity patterns. Given these two subregions' differential association with cognitive processes, we investigated the functional connectivity (FC) profile of both subregions through resting-state data to determine whether they are differentially affected in SCZ. Resting-state magnetic resonance imaging (MRI) scans were obtained from 120 patients and 172 healthy controls (HC) at 6 different MRI sites. The results showed differential FC patterns for the anterior and posterior parts of the right executive control-related DLPFC in SCZ with the parietal, the temporal and the cerebellar regions, along with a convergent reduction of connectivity with the striatum and the occipital cortex. An increased psychopathology level was linked to a higher difference in posterior vs. anterior FC for the left IFG/anterior insula, regions involved in higher-order cognitive processes. In sum, the current analysis demonstrated that even between two neighboring clusters connectivity could be differentially disrupted in SCZ. Lacking the necessary anatomical specificity, such notions may in fact be detrimental to a proper understanding of SCZ pathophysiology.
Details
- Title: Subtitle
- Differential Resting-State Connectivity Patterns of the Right Anterior and Posterior Dorsolateral Prefrontal Cortices (DLPFC) in Schizophrenia
- Creators
- Natalia Chechko - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen UniversityEdna C Cieslik - Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University DüsseldorfVeronika I Müller - Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University DüsseldorfThomas Nickl-Jockschat - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen UniversityBirgit Derntl - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen UniversityLydia Kogler - Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen UniversityAndré Aleman - Department of Neuroscience, University Medical Center Groningen, University of GroningenRenaud Jardri - Univ Lille, CNRS UMR 9193, SCALab and CHU Lille, Division of Psychiatry, CURE platform, Fontan HospitalIris E Sommer - Neuroscience Division, University Medical Centre Utrecht and Rudolf Magnus Institute for NeuroscienceOliver Gruber - Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg UniversitySimon B Eickhoff - Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf
- Resource Type
- Journal article
- Publication Details
- Frontiers in psychiatry, Vol.9(MAY), pp.211-211
- DOI
- 10.3389/fpsyt.2018.00211
- PMID
- 29892234
- NLM abbreviation
- Front Psychiatry
- ISSN
- 1664-0640
- eISSN
- 1664-0640
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 05/28/2018
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984070522702771
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