Journal article
Differential Sensitivity to Prevention Programming: A Dopaminergic Polymorphism-Enhanced Prevention Effect on Protective Parenting and Adolescent Substance Use
Health psychology, Vol.33(2), pp.182-191
02/2014
DOI: 10.1037/a0031253
PMCID: PMC3695005
PMID: 23379386
Abstract
Objective: The purpose of this study was to investigate a genetic moderation effect of dopamine receptor-4 gene (DRD4) alleles that have 7 or more repeats on the efficacy of a preventive intervention to deter rural African American adolescents' substance use. Methods: Adolescents (N = 502, M age = 16 years) were assigned randomly to the Strong African American Families-Teen (SAAF-T) program or to a control condition and were followed for 22 months. Adolescents provided data on substance use, and both adolescents and their primary caregivers provided data on intervention-targeted protective parenting practices. Results: Male adolescents who carried at least one allele of DRD4 with 7 or more repeats who were assigned to the control condition evinced more substance use across 22 months than did (a) carriers of at least one allele of DRD4 with 7 or more repeats who were assigned to SAAF-T or (b) adolescents assigned to either condition who carried two alleles of DRD4 with 6 or fewer repeats. These findings were mediated by DRD4 × SAAF-T interaction effects on increases in intervention-targeted protective parenting practices, a mediated moderation effect. Conclusions: The results imply that prevention effects on health-relevant outcomes for genetically susceptible individuals, such as carriers of at least one allele of DRD4 with 7 or more repeats, may be underestimated.
Details
- Title: Subtitle
- Differential Sensitivity to Prevention Programming: A Dopaminergic Polymorphism-Enhanced Prevention Effect on Protective Parenting and Adolescent Substance Use
- Creators
- Gene H Brody - Center for Family Research, University of GeorgiaYi-fu Chen - Center for Family Research, University of GeorgiaSteven R. H Beach - Center for Family Research, University of GeorgiaSteven M Kogan - Department of Child and Family Development, University of GeorgiaTianyi Yu - Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory UniversityRalph J DiClemente - Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory UniversityGina M Wingood - Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory UniversityMichael Windle - Department of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory UniversityRobert A Philibert - Department of Psychiatry, University of Iowa
- Contributors
- Anne E Kazak (Editor)
- Resource Type
- Journal article
- Publication Details
- Health psychology, Vol.33(2), pp.182-191
- DOI
- 10.1037/a0031253
- PMID
- 23379386
- PMCID
- PMC3695005
- NLM abbreviation
- Health Psychol
- ISSN
- 0278-6133
- eISSN
- 1930-7810
- Publisher
- American Psychological Association
- Grant note
- DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: R01DA021736 and P30DA027827
- Language
- English
- Date published
- 02/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry
- Record Identifier
- 9984004184902771
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