Journal article
Differential Synaptic Dynamics and Circuit Connectivity of Hippocampal and Thalamic Inputs to the Prefrontal Cortex
Cerebral cortex communications, Vol.1(1), tgaa084
2020
DOI: 10.1093/texcom/tgaa084
PMCID: PMC7750130
PMID: 33381761
Abstract
The medial prefrontal cortex (mPFC) integrates inputs from multiple subcortical regions including the mediodorsal nucleus of the thalamus (MD) and the ventral hippocampus (vHPC). How the mPFC differentially processes these inputs is not known. One possibility is that these two inputs target discreet populations of mPFC cells. Alternatively, individual prefrontal cells could receive convergent inputs but distinguish between both inputs based on synaptic differences, such as communication frequency. To address this, we utilized a dual wavelength optogenetic approach to stimulate MD and vHPC inputs onto single, genetically defined mPFC neuronal subtypes. Specifically, we compared the convergence and synaptic dynamics of both inputs onto mPFC pyramidal cells, and parvalbumin (PV)- and vasoactive intestinal peptide (VIP)-expressing interneurons. We found that all individual pyramidal neurons in layer 2/3 of the mPFC receive convergent input from both MD and vHPC. In contrast, PV neurons receive input biased from the MD, while VIP cells receive input biased from the vHPC. Independent of the target, MD inputs transferred information more reliably at higher frequencies (20 Hz) than vHPC inputs. Thus, MD and vHPC projections converge functionally onto mPFC pyramidal cells, but both inputs are distinguished by frequency-dependent synaptic dynamics and preferential engagement of discreet interneuron populations.
Details
- Title: Subtitle
- Differential Synaptic Dynamics and Circuit Connectivity of Hippocampal and Thalamic Inputs to the Prefrontal Cortex
- Creators
- Sarah Canetta - Columbia University Irving Medical CenterEric Teboul - New York State Psychiatric InstituteEmma Holt - New York State Psychiatric InstituteScott S Bolkan - Columbia University Irving Medical CenterNancy Padilla-Coreano - Columbia University Irving Medical CenterJoshua A Gordon - National Institute of Mental Health, Bethesda, MD 20892, USANeil L Harrison - Columbia University Irving Medical CenterChristoph Kellendonk - Columbia University Irving Medical Center
- Resource Type
- Journal article
- Publication Details
- Cerebral cortex communications, Vol.1(1), tgaa084
- DOI
- 10.1093/texcom/tgaa084
- PMID
- 33381761
- PMCID
- PMC7750130
- NLM abbreviation
- Cereb Cortex Commun
- ISSN
- 2632-7376
- eISSN
- 2632-7376
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 2020
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984945142502771
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