Journal article
Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development
Gene Expression Patterns, Vol.9(6), pp.444-453
2009
DOI: 10.1016/j.gep.2009.04.003
PMCID: PMC3023882
PMID: 19427409
Abstract
The development of the inner ear involves complex processes of morphological changes, patterning and cell fate specification that are under strict molecular control. SOX2 and SOX9 are SOX family transcription factors that are involved in the regulation of one or more of these processes. Previous findings have shown early expression of SOX9 in the otic placode and vesicle at E8.5–E9.5. Here we describe in detail, the expression pattern of SOX9 in the developing mouse inner ear beyond the otocyst stage and compare it with that of SOX2 from E9.5 to E18.5 using double fluorescence immunohistochemistry. We found that SOX9 was widely expressed in the otic epithelium, periotic mesenchyme and cartilaginous otic capsule. SOX2 persistently marked the prosensory and sensory epithelia. During the development of the sensory epithelia, SOX2 was initially expressed in all prosensory regions and later in both the supporting and hair cells up to E15.5, when its expression in hair cells gradually diminished. SOX9 expression overlapped with that of SOX2 in the prosensory and sensory region until E14.5 when its expression was restricted to supporting cells. This initial overlap but subsequent differential expression of SOX2 and SOX9 in the sensory epithelia, suggest that SOX2 and SOX9 may have distinct roles in molecular pathways that direct cells towards different cell fates.
Details
- Title: Subtitle
- Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development
- Creators
- Angel C.Y Mak - Department of Biochemistry, The University of Hong Kong, Li Ka Shing Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, ChinaIrene Y.Y Szeto - Department of Biochemistry, The University of Hong Kong, Li Ka Shing Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, ChinaBernd Fritzsch - Department of Biology, College of Liberal Arts and Sciences, 143 Biology Building, Iowa City, IA 52242-1324, USAKathryn S.E Cheah - Department of Biochemistry, The University of Hong Kong, Li Ka Shing Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
- Resource Type
- Journal article
- Publication Details
- Gene Expression Patterns, Vol.9(6), pp.444-453
- DOI
- 10.1016/j.gep.2009.04.003
- PMID
- 19427409
- PMCID
- PMC3023882
- NLM abbreviation
- Gene Expr Patterns
- ISSN
- 1567-133X
- eISSN
- 1872-7298
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 2009
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070444502771
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