Journal article
Differential cAMP Gating of Glutamatergic Signaling Regulates Long-Term State Changes in the Suprachiasmatic Circadian Clock
The Journal of neuroscience, Vol.20(20), pp.7830-7837
10/15/2000
DOI: 10.1523/JNEUROSCI.20-20-07830.2000
PMCID: PMC6772885
PMID: 11027248
Abstract
We investigated a role for cAMP/protein kinase A (PKA) in light/glutamate (GLU)-stimulated state changes of the mammalian circadian clock in the suprachiasmatic nucleus (SCN). Nocturnal GLU treatment elevated [cAMP]; however, agonists of cAMP/PKA did not mimic the effects of light/GLU. Coincident activation of cAMP/PKA enhanced GLU-stimulated state changes in early night but blocked light/GLU-induced state changes in the late night, whereas inhibition of cAMP/PKA reversed these effects. These responses are distinct from those mediated by mitogen-activated protein kinase (MAPK). MAPK inhibitors attenuated both GLU-induced state changes. Although GLU induced
mPer1
mRNA in both early and late night, inhibition of PKA blocked this event only in early night, suggesting that cellular mechanisms regulating
mPer1
are gated by the suprachiasmatic circadian clock. These data support a diametric gating role for cAMP/PKA in light/GLU-induced SCN state changes: cAMP/PKA promotes the effects of light/GLU in early night, but opposes them in late night.
Details
- Title: Subtitle
- Differential cAMP Gating of Glutamatergic Signaling Regulates Long-Term State Changes in the Suprachiasmatic Circadian Clock
- Creators
- Shelley A TischkauEve A GallmanGordon F BuchananMartha U Gillette
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.20(20), pp.7830-7837
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.20-20-07830.2000
- PMID
- 11027248
- PMCID
- PMC6772885
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 10/15/2000
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020713602771
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