Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice

Robin K Yuan; Matthew R Lopez; Manuel-Miguel Ramos-Alvarez; Marc E Normandin; Arthur S Thomas; David S Uygun; Vanessa R Cerda; Amandine E Grenier; Matthew T Wood; Celia M Gagliardi; Herminio Guajardo; Isabel A Muzzio

doi:10.1016/j.celrep.2021.109234

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Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice

Journal article

Open access

Peer reviewed

Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice

Robin K Yuan, Matthew R Lopez, Manuel-Miguel Ramos-Alvarez, Marc E Normandin, Arthur S Thomas, David S Uygun, Vanessa R Cerda, Amandine E Grenier, Matthew T Wood, Celia M Gagliardi, …

Cell reports (Cambridge), Vol.35(11), pp.109234-109234

06/15/2021

DOI: 10.1016/j.celrep.2021.109234

PMCID: PMC8545463

PMID: 34133936

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Abstract

Poor sleep quality is associated with age-related cognitive decline, and whether reversal of these alterations is possible is unknown. In this study, we report how sleep deprivation (SD) affects hippocampal representations, sleep patterns, and memory in young and old mice. After training in a hippocampus-dependent object-place recognition (OPR) task, control animals sleep ad libitum, although experimental animals undergo 5 h of SD, followed by recovery sleep. Young controls and old SD mice exhibit successful OPR memory, whereas young SD and old control mice are impaired. Successful performance is associated with two cellular phenotypes: (1) "context" cells, which remain stable throughout training and testing, and (2) "object configuration" cells, which remap when objects are introduced to the context and during testing. Additionally, effective memory correlates with spindle counts during non-rapid eye movement (NREM)/rapid eye movement (REM) sigma transitions. These results suggest SD may serve to ameliorate age-related memory deficits and allow hippocampal representations to adapt to changing environments.

Aging - pathology

Animals

Bayes Theorem

Behavior, Animal

Corticosterone - blood

Delta Rhythm - physiology

Hippocampus - pathology

Hippocampus - physiopathology

Male

Memory - physiology

Mice, Inbred C57BL

Place Cells - pathology

Sleep - physiology

Sleep Deprivation - blood

Sleep Deprivation - physiopathology

Task Performance and Analysis

Theta Rhythm - physiology

Details

Title: Subtitle: Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice
Creators: Robin K Yuan - Brigham and Women's Hospital
Matthew R Lopez - The University of Texas at San Antonio
Manuel-Miguel Ramos-Alvarez - Universidad de Jaén
Marc E Normandin - The University of Texas at San Antonio
Arthur S Thomas - University of Pennsylvania
David S Uygun - VA Boston Healthcare System
Vanessa R Cerda - The University of Texas at San Antonio
Amandine E Grenier - The University of Texas at San Antonio
Matthew T Wood - The University of Texas at San Antonio
Celia M Gagliardi - The University of Texas at San Antonio
Herminio Guajardo - The University of Texas at San Antonio
Isabel A Muzzio - The University of Texas at San Antonio
Resource Type: Journal article
Publication Details: Cell reports (Cambridge), Vol.35(11), pp.109234-109234
DOI: 10.1016/j.celrep.2021.109234
PMID: 34133936
PMCID: PMC8545463
NLM abbreviation: Cell Rep
ISSN: 2211-1247
eISSN: 2211-1247
Grant note: R25 GM060655 / NIGMS NIH HHS F32 HL143893 / NHLBI NIH HHS IK2 BX004905 / BLRD VA F31 MH105161 / NIMH NIH HHS R01 MH123260 / NIMH NIH HHS
Language: English
Date published: 06/15/2021
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984295023902771

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