Journal article
Differential effects of L-dopa and apomorphine on glucagon secretion in man: evidence against central dopaminergic stimulation of glucagon
The journal of clinical endocrinology and metabolism, Vol.45(6), pp.1154-1158
12/1977
DOI: 10.1210/jcem-45-6-1154
PMID: 591612
Abstract
In 6 normal subjects, L-dopa (500 mg PO) and apomorphine (0.6 mg sc) increased circulating growth hormone and suppressed prolactin levels in a parallel and quantitatively similar fashion, but only L-dopa induced a rise in plasma glucagon, glucose, and insulin levels. The failure of apomorphine to affect glucagon secretion, despite a substantial effect on growth hormone and prolactin, was also observed in insulin-dependent diabetics known to exhibit A-cell hyperresponsiveness to various stimuli. In view of the highly dissimilar molecular and pharmacologic characteristics of L-dopa and apomorphine, these data do not exclude a local dopaminergic effect of L-dopa at the pancreatic level, but strongly militate against a central dopaminergic pathway for glucagon stimulation.
Details
- Title: Subtitle
- Differential effects of L-dopa and apomorphine on glucagon secretion in man: evidence against central dopaminergic stimulation of glucagon
- Creators
- M LorenziE TsalikianN V BohannonJ E GerichJ H KaramP H Forsham
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.45(6), pp.1154-1158
- DOI
- 10.1210/jcem-45-6-1154
- PMID
- 591612
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Language
- English
- Date published
- 12/1977
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093375802771
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