Journal article
Differential effects of hyperglycemia and hyperinsulinemia on leucine rate of appearance in normal humans
The journal of clinical endocrinology and metabolism, Vol.76(1), pp.203-206
01/1993
DOI: 10.1210/jcem.76.1.8093620
PMID: 8093620
Abstract
To determine the independent effects of insulin and glucose on the rate of appearance of leucine in humans, five normal volunteers were studied using a pancreatic clamp with sequential insulin infusions of 1.8, 3.6 and 7.2 pmol kg/min-1. On each of three separate occasions, the plasma glucose level was maintained at 5.0, 9.4 or 14 mM. The rate of appearance of leucine was similar at each insulin infusion rate regardless of the ambient glucose concentration or the glucose infusion rate. These studies demonstrate that during insulin and glucose infusion, insulin, but neither the plasma glucose concentration nor the rate of glucose utilization, primarily regulates leucine flux (a reflection of endogenous whole body proteolysis) in normal humans.
Details
- Title: Subtitle
- Differential effects of hyperglycemia and hyperinsulinemia on leucine rate of appearance in normal humans
- Creators
- V J HeilingP J CampbellI S GottesmanE TsalikianB BeaufrereJ E GerichM W Haymond
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.76(1), pp.203-206
- DOI
- 10.1210/jcem.76.1.8093620
- PMID
- 8093620
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Language
- English
- Date published
- 01/1993
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093211202771
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