Journal article
Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila
microPublication biology, Vol.2021
05/24/2021
DOI: 10.17912/micropub.biology.000385
PMCID: PMC8133701
PMID: 34027314
Abstract
Oxidative stress is thought to be a major contributor to aging processes. Here, we report differential effects on neurotransmission caused by loss-of-function mutations of Superoxide dismutase 1 (Sod1) and by paraquat (PQ) feeding in Drosophila. We demonstrated alterations in Sod1 mutants; the larval neuromuscular junction displayed supernumerary discharges and the adult giant-fiber escape pathway showed increased latency and poor response to repetitive high-frequency stimulation. Even though the concentrations used led to motor coordination defects and lethality, PQ feeding failed to reproduce such performance deficits in these larval and adult preparations, indicating mechanistic distinctions between these genetic and pharmacological manipulations of oxidative stress.
Details
- Title: Subtitle
- Differential effects on neuromuscular physiology between Sod1 loss-of-function mutation and paraquat-induced oxidative stress in Drosophila
- Creators
- Atsushi UedaAtulya IyengarChun-Fang Wu
- Resource Type
- Journal article
- Publication Details
- microPublication biology, Vol.2021
- DOI
- 10.17912/micropub.biology.000385
- PMID
- 34027314
- PMCID
- PMC8133701
- NLM abbreviation
- MicroPubl Biol
- ISSN
- 2578-9430
- eISSN
- 2578-9430
- Language
- English
- Date published
- 05/24/2021
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984530394002771
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