Journal article
Differential induction of cytochrome P-450 by the enantiomers of trans-stilbene oxide
Biochemical pharmacology, Vol.36(24), pp.4355-4359
1987
DOI: 10.1016/0006-2952(87)90684-8
PMID: 2825725
Abstract
Optically pure (+)- and (−)-
trans-stilbene oxide (TSO) enantiomers were administered to immature male Sprague-Dawley rats. (+)-TSO was the more potent inducer of liver microsomal cytochrome P-450-dependent monooxygenases. The greater potency of (+)-TSO may be explained on the basis of stereoselective metabolism since a far greater concentration of TSO was found in liver microsomes of (+)-TSO-treated rats. Furthermore, of the enzymes known to metabolize TSO, cytosolic epoxide hydrolase turned over the (−)-TSO enantiomer at a faster rate, consistent with the greater persistence of the (+)-enantiomer. Although this report is of chiral effects in potency of enzyme induction, stereoselective metabolism (i.e. disposition) rather than inherent structural characteristics (recognition) may be responsible for these effects.
Details
- Title: Subtitle
- Differential induction of cytochrome P-450 by the enantiomers of trans-stilbene oxide
- Creators
- Petra Rauch - Institute of Toxicology, University of Mainz, D-6500 Mainz, Federal Republic of GermanyMichael Püttmann - Institute of Toxicology, University of Mainz, D-6500 Mainz, Federal Republic of GermanyFranz Oesch - Institute of Toxicology, University of Mainz, D-6500 Mainz, Federal Republic of GermanyYoshio Okamoto - Department of Chemistry, Faculty of Engineering Science, Toyonaka, Osaka560, JapanLarry W Robertson - Institute of Toxicology, University of Mainz, D-6500 Mainz, Federal Republic of Germany
- Resource Type
- Journal article
- Publication Details
- Biochemical pharmacology, Vol.36(24), pp.4355-4359
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0006-2952(87)90684-8
- PMID
- 2825725
- ISSN
- 0006-2952
- eISSN
- 1873-2968
- Language
- English
- Date published
- 1987
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002582602771
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