Differential presentation of an altered peptide within fetal central and peripheral organs supports an avidity model for thymic T cell development and implies a peripheral readjustment for activation

Kevin L Legge; Booki Min; Christopher Pack; Jacque Caprio; Habib Zaghouani

doi:10.4049/jimmunol.162.10.5738

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Differential presentation of an altered peptide within fetal central and peripheral organs supports an avidity model for thymic T cell development and implies a peripheral readjustment for activation

Journal article

Peer reviewed

Differential presentation of an altered peptide within fetal central and peripheral organs supports an avidity model for thymic T cell development and implies a peripheral readjustment for activation

Kevin L Legge, Booki Min, Christopher Pack, Jacque Caprio and Habib Zaghouani

The Journal of immunology (1950), Vol.162(10), pp.5738-5746

05/15/1999

DOI: 10.4049/jimmunol.162.10.5738

PMID: 10229806

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Abstract

Altered self peptides may drive T cell development by providing avidity of interactions low enough to potentiate positive selection but not powerful enough to trigger programmed cell death. Since the peptide repertoire in both central and peripheral organs is nearly the same, interactions of these peptides with T cells in the thymus would have to be different from those taking place in the periphery; otherwise, T cell development and maturation would result in either autoimmunity or T cell deficiency. Herein, a self and an altered self peptide were delivered to fetuses, and their presentation as well as the consequence of such presentation on T cell development were assessed. The results indicate that the self peptide was presented in both central and peripheral fetal organs and that such presentation abolished T cell responses to both peptides during adult life. However, the altered peptide, although presented in vivo as well as in vitro by splenic cells, was unable to stimulate a specific T cell clone when the presenting cells were of thymic origin and allowed offspring to be responsive to both peptides. These findings indicate that central and peripheral organs accommodate selection and peripheral survival of T cells by promoting differential altered peptide presentation.

Pregnancy

Recombinant Fusion Proteins - immunology

Spleen - immunology

Lymphocyte Activation

Maternal-Fetal Exchange

Immune Tolerance

Lymph Nodes - immunology

Mice, Inbred Strains

Encephalomyelitis, Autoimmune, Experimental

Models, Immunological

Animals

Proteolipids - immunology

Antigen Presentation

Peptide Fragments - immunology

Clone Cells - immunology

Female

T-Lymphocytes - immunology

Mice

Thymus Gland - embryology

Immune System - embryology

Details

Title: Subtitle: Differential presentation of an altered peptide within fetal central and peripheral organs supports an avidity model for thymic T cell development and implies a peripheral readjustment for activation
Creators: Kevin L Legge - Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
Booki Min
Christopher Pack
Jacque Caprio
Habib Zaghouani
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.162(10), pp.5738-5746
DOI: 10.4049/jimmunol.162.10.5738
PMID: 10229806
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Language: English
Date published: 05/15/1999
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984046823002771

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