Journal article
Differential role of tumor necrosis factor receptors in TNBS colitis
Inflammatory bowel diseases, Vol.11(6), pp.533-540
06/2005
DOI: 10.1097/01.MIB.0000163698.34592.30
PMID: 15905700
Abstract
Background: Tumor necrosis factor α (TNFα) plays a central role in the pathology of T helper 1‐mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored.
Methods: Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacking each of the TNF receptors (TNFRs) and in wild‐type mice. TNFR1−/− mice lost more weight, became hypothermic, and had increased mortality compared with wild‐type C57Bl/6 mice. TNFR2−/− mice, however, lost less weight, had normal temperatures, and had improved survival.
Results: Despite the improved clinical outcomes in TNFR2−/− mice, TNFα levels were increased in these mice.
Conclusions: TNFα signaling through TNFR1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease.
Details
- Title: Subtitle
- Differential role of tumor necrosis factor receptors in TNBS colitis
- Creators
- Dawn R EbachRodney NewberryWilliam F Stenson
- Resource Type
- Journal article
- Publication Details
- Inflammatory bowel diseases, Vol.11(6), pp.533-540
- DOI
- 10.1097/01.MIB.0000163698.34592.30
- PMID
- 15905700
- NLM abbreviation
- Inflamm Bowel Dis
- ISSN
- 1078-0998
- eISSN
- 1536-4844
- Publisher
- Lippincott Williams & Wilkins, Inc
- Number of pages
- 8
- Grant note
- The Washington University Digestive Disease Research Center ((P30DK052574)) Crohn's and Colitis Foundation of America Research Fellowship Award (DK55753 and DK33165) National Institutes of Health Institutional Training Grant (T32 HD‐07409)
- Language
- English
- Date published
- 06/2005
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984093600302771
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