Differential susceptibility to parenting among African American youths: testing the DRD4 hypothesis

Steven R H Beach; Gene H Brody; Man-Kit Lei; Robert A Philibert

doi:10.1037/a0020835

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Differential susceptibility to parenting among African American youths: testing the DRD4 hypothesis

Journal article

Peer reviewed

Differential susceptibility to parenting among African American youths: testing the DRD4 hypothesis

Steven R H Beach, Gene H Brody, Man-Kit Lei and Robert A Philibert

Journal of family psychology, Vol.24(5), pp.513-521

10/2010

DOI: 10.1037/a0020835

PMCID: PMC2958690

PMID: 20954761

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Abstract

To test the differential susceptibility to parenting hypothesis, a 4-wave, randomized prevention design was used to examine the impact of the Strong African American Families program on past-month substance use across 29 months as a function of DRD4 genotype. Youths (N = 337; M age = 11.65 years) were assigned randomly to treatment condition. Those carrying a 7-repeat allele showed greater differential response to intervention vs. control than those with two 4-repeat alleles. Control youths but not treatment youths with a 7-repeat allele reported increases in past-month substance use across the 29-month study period, but this pattern did not emerge for those with the 4-repeat allele. Supporting the differential susceptibility to parenting hypothesis, the results suggest a greater preventive effect for youths carrying a 7-repeat allele, a role for DRD4 in the escalation of substance use during adolescence, and potential for an enhanced understanding of early-onset substance use.

Genetic Predisposition to Disease - psychology

Genetic Predisposition to Disease - genetics

Follow-Up Studies

Humans

Male

Receptors, Dopamine D4 - genetics

Substance-Related Disorders - genetics

African Americans - statistics & numerical data

Parenting - psychology

Substance-Related Disorders - prevention & control

Substance-Related Disorders - psychology

Adult

Female

Child

African Americans - psychology

Details

Title: Subtitle: Differential susceptibility to parenting among African American youths: testing the DRD4 hypothesis
Creators: Steven R H Beach - Institute for Behavioral Research, University of Georgia, Athens, GA 30602, USA. srhbeach@uga.edu
Gene H Brody
Man-Kit Lei
Robert A Philibert
Resource Type: Journal article
Publication Details: Journal of family psychology, Vol.24(5), pp.513-521
DOI: 10.1037/a0020835
PMID: 20954761
PMCID: PMC2958690
NLM abbreviation: J Fam Psychol
ISSN: 0893-3200
eISSN: 1939-1293
Publisher: United States
Grant note: P30 DA027827 / NIDA NIH HHS R01 AA012768 / NIAAA NIH HHS 5R01AA012768-08 / NIAAA NIH HHS 5R01DA01923-04S1 / NIDA NIH HHS 1P30DA027827 / NIDA NIH HHS 3R01AA012768-08S1 / NIAAA NIH HHS
Language: English
Date published: 10/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003421602771

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