Journal article
Differential sympathetic nerve responses to nitric oxide synthase inhibition in anesthetized rats
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.269(4), pp.R807-R813
10/01/1995
DOI: 10.1152/ajpregu.1995.269.4.R807
PMID: 7485597
Abstract
Recent studies have suggested that the interaction between the sympathetic nervous system and nitric oxide (NO) or nitrosyl factors may be an important means by which arterial blood pressure is regulated. We investigated whether NO synthase (NOS) inhibition modulates basal sympathetic nerve discharge (SND) in baroreceptor-innervated and -denervated, chloralose-anesthetized Sprague-Dawley rats. We recorded mean arterial pressure (MAP), renal SND, and lumbar SND before and after administration of the NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME, 20 mg/kg iv). Two minutes after L-NAME administration in baroreceptor-innervated rats, MAP increased (+23 +/- 3 mmHg), whereas renal (-45 +/- 6%, n = 7) and lumbar (-35 +/- 2%, n = 6) SND significantly decreased from control levels. These changes persisted for up to 20 min after L-NAME administration. In baroreceptor-denervated rats, L-NAME increased MAP (+40 +/- 6 mmHg) and decreased lumbar SND (n = 7) (-37 +/- 10% from control at 20 min post-L-NAME). In contrast, renal SND progressively increased (+33 +/- 8% at 20 min post-L-NAME) from control after L-NAME administration in baroreceptor-denervated rats (n = 7). These results demonstrate that NOS inhibition can produce nonuniform changes in SND in baroreceptor-denervated rats and suggest that endogenous nitrosyl factors provide tonic excitation to lumbar SND, whereas they provide a tonic restraint to renal SND.
Details
- Title: Subtitle
- Differential sympathetic nerve responses to nitric oxide synthase inhibition in anesthetized rats
- Creators
- Tadakazu Hirai - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USATimothy I Musch - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USADonald A Morgan - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USAKevin C Kregel - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USADale E Claassen - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USAJoel G Pickar - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USAStephen J Lewis - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USAMichael J Kenney - Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USA
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.269(4), pp.R807-R813
- DOI
- 10.1152/ajpregu.1995.269.4.R807
- PMID
- 7485597
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 10/01/1995
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology; Neuroscience and Pharmacology; Provost Office Administration; Health and Human Physiology
- Record Identifier
- 9984213308402771
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