Journal article
Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus
Learning & memory (Cold Spring Harbor, N.Y.), Vol.13(2), pp.135-142
03/2006
DOI: 10.1101/lm.86906
PMCID: PMC1409829
PMID: 16547164
Abstract
Classical fear conditioning requires the recognition of conditioned stimuli (CS) and the association of the CS with an aversive stimulus. We used Affymetrix oligonucleotide microarrays to characterize changes in gene expression compared to naive mice in both the amygdala and the hippocampus 30 min after classical fear conditioning and 30 min after exposure to the CS in the absence of an aversive stimulus. We found that in the hippocampus, levels of gene regulation induced by classical fear conditioning were not significantly greater than those induced by CS alone, whereas in the amygdala, classical fear conditioning did induce significantly greater levels of gene regulation compared to the CS. Computational studies suggest that transcriptional changes in the hippocampus and amygdala are mediated by large and overlapping but distinct combinations of molecular events. Our results demonstrate that an increase in gene regulation in the amygdala was partially correlated to associative learning and partially correlated to nonassociative components of the task, while gene regulation in the hippocampus was correlated to nonassociative components of classical fear conditioning, including configural learning.
Details
- Title: Subtitle
- Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus
- Creators
- Michael B Keeley - Department of BiologyMarcelo A Wood - Department of BiologyCarolina Isiegas - Department of BiologyJoel Stein - Department of BiologyKevin Hellman - Committee on Neurobiology in the Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, Illinois 60637, USASridhar Hannenhalli - Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USATed Abel - Department of Biology
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.13(2), pp.135-142
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.86906
- PMID
- 16547164
- PMCID
- PMC1409829
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Alternative title
- Differential response in amygdala and hippocampus
- Language
- English
- Date published
- 03/2006
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065839002771
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