Journal article
Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1
Immunity (Cambridge, Mass.), Vol.33(2), pp.229-240
08/27/2010
DOI: 10.1016/j.immuni.2010.08.002
PMCID: PMC2928475
PMID: 20727791
Abstract
T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the canonical Wnt pathway and is essential for normal T cell development. However, its physiological roles in mature CD8
+
T cell responses are unknown. Here we showed that TCF-1 deficiency limited proliferation of CD8
+
effector T cells and impaired their differentiation towards a central memory phenotype. Moreover, TCF-1-deficient memory CD8
+
T cells were progressively lost over time, exhibiting reduced expression of the anti-apoptotic molecule Bcl-2, interleukin-2 receptor β chain and diminished IL-15-driven proliferation. TCF-1 was directly associated with the
Eomes
allele and the Wnt-TCF-1 pathway was necessary and sufficient for optimal Eomes expression in naïve and memory CD8
+
T cells. Importantly, forced expression of Eomes partly protected TCF-1-deficient memory CD8
+
T cells from time-dependent attrition. Our studies thus identify TCF-1 as a critical player in a transcriptional program that regulates memory CD8 differentiation and longevity.
Details
- Title: Subtitle
- Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1
- Creators
- Xinyuan Zhou - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAShuyang Yu - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USADong-Mei Zhao - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAJohn T Harty - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAVladimir P Badovinac - Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAHai-Hui Xue - Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.33(2), pp.229-240
- DOI
- 10.1016/j.immuni.2010.08.002
- PMID
- 20727791
- PMCID
- PMC2928475
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 08/27/2010
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047659802771
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