Difficulty Achieving Vitamin D Sufficiency With High-Dose Oral Repletion Therapy in Infants With Cholestasis

Melissa Jensen; Maisam Abu-El-Haija; Warren Bishop; Riad M Rahhal

doi:10.1097/MPG.0000000000000751

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Difficulty Achieving Vitamin D Sufficiency With High-Dose Oral Repletion Therapy in Infants With Cholestasis

Journal article

Peer reviewed

Difficulty Achieving Vitamin D Sufficiency With High-Dose Oral Repletion Therapy in Infants With Cholestasis

Melissa Jensen, Maisam Abu-El-Haija, Warren Bishop and Riad M Rahhal

Journal of pediatric gastroenterology and nutrition, Vol.61(2), pp.187-189

08/2015

DOI: 10.1097/MPG.0000000000000751

PMID: 25651487

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Abstract

Oral high-dose repletion vitamin D therapy, also known as stoss therapy, can be effective in the treatment of nutritional vitamin D deficiency rickets in infants and young children without liver disease and in patients with cystic fibrosis. There is no literature about this approach in infants with new-onset cholestasis. This was a retrospective chart review of infants with cholestasis from March 2010 to March 2012 at a pediatric tertiary care center. Four cases satisfied the inclusion criteria, and were described in detail. All of the patients received oral high-dose repletion therapy with ergocalciferol (vitamin D2) 300,000 IU daily for 2 to 3 days. Follow-up vitamin D levels approximately 4 weeks later showed failure to achieve sufficiency levels (>20 ng/dL) in any patient. Unlike infants without liver disease, use of oral high-dose repletion therapy may not be adequate as treatment of vitamin D deficiency in the setting of cholestasis.

Tertiary Care Centers

Cholestasis - complications

Administration, Oral

Humans

Vitamin D Deficiency - drug therapy

Infant

Male

Biliary Atresia - complications

Vitamin D - blood

Vitamin D Deficiency - diagnosis

alpha 1-Antitrypsin Deficiency - complications

Treatment Failure

Ergocalciferols - administration & dosage

Female

Vitamin D - analogs & derivatives

Retrospective Studies

Vitamin D Deficiency - etiology

Details

Title: Subtitle: Difficulty Achieving Vitamin D Sufficiency With High-Dose Oral Repletion Therapy in Infants With Cholestasis
Creators: Melissa Jensen - Division of Pediatric Gastroenterology, Sanford Children's Specialty Clinic, Sioux Falls, SD †Division of Pediatric Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH ‡Department of Pediatrics, Division of Pediatric Gastroenterology, University of Iowa, Iowa City
Maisam Abu-El-Haija
Warren Bishop
Riad M Rahhal
Resource Type: Journal article
Publication Details: Journal of pediatric gastroenterology and nutrition, Vol.61(2), pp.187-189
DOI: 10.1097/MPG.0000000000000751
PMID: 25651487
ISSN: 0277-2116
eISSN: 1536-4801
Language: English
Date published: 08/2015
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition; Internal Medicine
Record Identifier: 9984093213502771

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