Diffusion Tensor Imaging in Preclinical Huntington’s Disease

Vincent A Magnotta; Jinsuh Kim; Tim Koscik; Leigh J Beglinger; Daisy Espinso; Doug Langbehn; Peg Nopoulos; Jane S Paulsen

doi:10.1007/s11682-008-9051-2

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Diffusion Tensor Imaging in Preclinical Huntington’s Disease

Journal article

Open access

Peer reviewed

Diffusion Tensor Imaging in Preclinical Huntington’s Disease

Vincent A Magnotta, Jinsuh Kim, Tim Koscik, Leigh J Beglinger, Daisy Espinso, Doug Langbehn, Peg Nopoulos and Jane S Paulsen

Brain imaging and behavior, Vol.3(1), pp.77-84

03/01/2009

DOI: 10.1007/s11682-008-9051-2

PMCID: PMC3057188

PMID: 21415933

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Abstract

Diffusion tensor imaging was used to study brain related changes in white matter that may be associated with Huntington’s Disease progression. Thirty-one preclinical gene-mutation carriers were imaged cross-sectionally using diffusion tensor and anatomical brain imaging. Subjects were individuals who had a known gene mutation for HD but did not manifest motor diagnostic criteria for HD. Fractional anisotropy scalar maps showed a positive correlation with five year probability of diagnosis (based upon gene repeat length and current age) in the putamen and a negative correlation in the external capsule. This study shows that scalar maps generated from diffusion tensor imaging may be directly related to the earliest stages of disease progression within HD, even before a diagnosis is given. Findings suggest that DTI measures, therefore, may have the ability to act as a biomarker for disease progression in clinical trials of pre-manifest subjects.

presymptomatic

fractional anisotropy

Huntington’s disease

preclinical

Diffusion tensor imaging

Details

Title: Subtitle: Diffusion Tensor Imaging in Preclinical Huntington’s Disease
Creators: Vincent A Magnotta - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Jinsuh Kim - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Tim Koscik - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Leigh J Beglinger - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Daisy Espinso - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Doug Langbehn - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Peg Nopoulos - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Jane S Paulsen - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52245
Resource Type: Journal article
Publication Details: Brain imaging and behavior, Vol.3(1), pp.77-84
DOI: 10.1007/s11682-008-9051-2
PMID: 21415933
PMCID: PMC3057188
NLM abbreviation: Brain Imaging Behav
ISSN: 1931-7557
eISSN: 1931-7565
Language: English
Date published: 03/01/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984003478002771

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