Journal article
Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models
Investigative ophthalmology & visual science, Vol.62(10), pp.21-21
08/02/2021
DOI: 10.1167/iovs.62.10.21
PMCID: PMC8383913
PMID: 34410298
Abstract
PurposeTo characterize the visual pathway integrity of five glaucoma animal models using diffusion tensor imaging (DTI). MethodsTwo experimentally induced and three genetically determined models of glaucoma were evaluated. For inducible models, chronic IOP elevation was achieved via intracameral injection of microbeads or laser photocoagulation of the trabecular meshwork in adult rodent eyes. For genetic models, the DBA/2J mouse model of pigmentary glaucoma, the LTBP2 mutant feline model of congenital glaucoma, and the transgenic TBK1 mouse model of normotensive glaucoma were compared with their respective genetically matched healthy controls. DTI parameters, including fractional anisotropy, axial diffusivity, and radial diffusivity, were evaluated along the optic nerve and optic tract. ResultsSignificantly elevated IOP relative to controls was observed in each animal model except for the transgenic TBK1 mice. Significantly lower fractional anisotropy and higher radial diffusivity were observed along the visual pathways of the microbead- and laser-induced rodent models, the DBA/2J mice, and the LTBP2-mutant cats compared with their respective healthy controls. The DBA/2J mice also exhibited lower axial diffusivity, which was not observed in the other models examined. No apparent DTI change was observed in the transgenic TBK1 mice compared with controls. ConclusionsChronic IOP elevation was accompanied by decreased fractional anisotropy and increased radial diffusivity along the optic nerve or optic tract, suggestive of disrupted microstructural integrity in both inducible and genetic glaucoma animal models. The effects on axial diffusivity differed between models, indicating that this DTI metric may represent different aspects of pathological changes over time and with severity.
Details
- Title: Subtitle
- Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models
- Creators
- Max K Colbert - New York University School of MedicineLeon C Ho - University of PittsburghYolandi van der Merwe - University of PittsburghXiaoling Yang - University of PittsburghGillian J McLellan - University of Wisconsin–MadisonSamuel A Hurley - University of Wisconsin–MadisonAaron S Field - University of Wisconsin–MadisonHongmin Yun - University of PittsburghYiqin Du - University of PittsburghIan P Conner - University of PittsburghCarlos Parra - New York University School of MedicineMuneeb A Faiq - New York University School of MedicineJohn H Fingert - University of IowaGadi Wollstein - New York University School of MedicineJoel S Schuman - New York University School of MedicineKevin C Chan - New York University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.62(10), pp.21-21
- DOI
- 10.1167/iovs.62.10.21
- PMID
- 34410298
- PMCID
- PMC8383913
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Language
- English
- Date published
- 08/02/2021
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984180937202771
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