Journal article
Diffusion tensor imaging reveals no white matter impairments among adults with autism spectrum disorder
Psychiatry research. Neuroimaging, Vol.233(1), pp.64-72
07/30/2015
DOI: 10.1016/j.pscychresns.2015.05.003
PMID: 26032898
Abstract
Abnormalities within white matter (WM) have been identified in autism spectrum disorder (ASD). Although there is some support for greater neurobiological deficits among females with ASD, there is little research investigating sex differences in WM in ASD. We used diffusion tensor imaging (DTI) to investigate WM aberration in 25 adults with high functioning ASD and 24 age-, sex- and IQ matched controls. Tract based spatial statistics (TBSS) was used to explore differences in WM in major tract bundles. The effects of biological sex were also investigated. TBSS revealed no differences in fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), or axial diffusivity (AD) between groups. There were no effects of biological sex. We consider whether methodological differences between past studies have contributed to the highly heterogeneous findings in the literature. Finally, we suggest that, among a high functioning sample of adults with ASD, differences in WM microstructure may not be related to clinical impairment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Details
- Title: Subtitle
- Diffusion tensor imaging reveals no white matter impairments among adults with autism spectrum disorder
- Creators
- Melissa Kirkovski - The Alfred HospitalPeter G. Enticott - Monash UniversityJerome J. Maller - Monash UniversitySusan L. Rossell - Swinburne University of TechnologyPaul B. Fitzgerald - Monash University
- Resource Type
- Journal article
- Publication Details
- Psychiatry research. Neuroimaging, Vol.233(1), pp.64-72
- DOI
- 10.1016/j.pscychresns.2015.05.003
- PMID
- 26032898
- NLM abbreviation
- Psychiatry Res Neuroimaging
- ISSN
- 0925-4927
- eISSN
- 1872-7506
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- Career Development Grant from the National Health and Medical Research Council (NHMRC); National Health & Medical Research Council (NHMRC) of Australia 606907 / NHMRC Practitioner Fellowship; National Health & Medical Research Council (NHMRC) of Australia Career Development Fellowship from the National Health and Medical Research Council (NHMRC); National Health & Medical Research Council (NHMRC) of Australia
- Language
- English
- Date published
- 07/30/2015
- Academic Unit
- Radiology
- Record Identifier
- 9984848420302771
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