Digital tomosynthesis (DTS) for quantitative assessment of trabecular microstructure in human vertebral bone

Woong Kim; Daniel Oravec; Srikant Nekkanty; Janardhan Yerramshetty; Edward A Sander; George W Divine; Michael J Flynn; Yener N Yeni

doi:10.1016/j.medengphy.2014.11.005

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Digital tomosynthesis (DTS) for quantitative assessment of trabecular microstructure in human vertebral bone

Journal article

Peer reviewed

Digital tomosynthesis (DTS) for quantitative assessment of trabecular microstructure in human vertebral bone

Woong Kim, Daniel Oravec, Srikant Nekkanty, Janardhan Yerramshetty, Edward A Sander, George W Divine, Michael J Flynn and Yener N Yeni

Medical engineering & physics, Vol.37(1), pp.109-120

01/2015

DOI: 10.1016/j.medengphy.2014.11.005

PMID: 25498138

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Abstract

Digital tomosynthesis (DTS) provides slice images of an object using conventional radiographic methods with high in-plane resolution. The objective of this study was to explore the potential of DTS for describing microstructural, stiffness and stress distribution properties of vertebral cancellous bone. Forty vertebrae (T6, T8, T11, and L3) from 10 cadavers (63–90 years) were scanned using microCT and DTS. Anisotropy (μCT.DA), and the specimen-average and standard deviation of trabecular bone volume fraction (BV/TV), thickness (Tb.Th), number (Tb.N) and separation (Tb.Sp) were obtained using stereology. Apparent modulus (EFEM), and the magnitude (VMExp/σapp) and variability (VMCV) of trabecular stresses were calculated using microCT-based finite element modeling. Mean intercept length, line fraction deviation and fractal parameters were obtained from coronal DTS slices, then correlated with stereological and finite element parameters using linear regression models. Twenty-one DTS parameters (out of 27) correlated to BV/TV, Tb.Th, Tb.N, Tb.Sp and/or μCT.DA (p<0.0001–p<0.05). DTS parameters increased the explained variability in EFEM and VMCV (by 9–11% and 13–19%, respectively; p<0.0001–p<0.04) over that explained by BV/TV. In conclusion, DTS has potential for quantitative assessment of cancellous bone and may be used as a modality complementary to those measuring bone mass for assessing spinal fracture risk.

Digital tomosynthesis

Heterogeneity

Fractal dimension

Stress distribution

Spine

Line fraction deviation

Finite element analysis

Bone biomechanics

Lacunarity

Microcomputed tomography

Details

Title: Subtitle: Digital tomosynthesis (DTS) for quantitative assessment of trabecular microstructure in human vertebral bone
Creators: Woong Kim - Bone and Joint Center, Henry Ford Hospital, Detroit, MI, United States
Daniel Oravec - Bone and Joint Center, Henry Ford Hospital, Detroit, MI, United States
Srikant Nekkanty - Bone and Joint Center, Henry Ford Hospital, Detroit, MI, United States
Janardhan Yerramshetty - Bone and Joint Center, Henry Ford Hospital, Detroit, MI, United States
Edward A Sander - Department of Biomedical Engineering, The University of Iowa, Iowa City, IA, United States
George W Divine - Department of Public Health Science, Henry Ford Hospital, Detroit, MI, United States
Michael J Flynn - Bone and Joint Center, Henry Ford Hospital, Detroit, MI, United States
Yener N Yeni - Bone and Joint Center, Henry Ford Hospital, Detroit, MI, United States
Resource Type: Journal article
Publication Details: Medical engineering & physics, Vol.37(1), pp.109-120
DOI: 10.1016/j.medengphy.2014.11.005
PMID: 25498138
NLM abbreviation: Med Eng Phys
ISSN: 1350-4533
eISSN: 1873-4030
Publisher: Elsevier Ltd
Language: English
Date published: 01/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
Record Identifier: 9984064568702771

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