Journal article
Digoxin Is Associated With Increased Shock Events and Electrical Storms in Patients With Implantable Cardioverter Defibrillators
Journal of cardiovascular pharmacology and therapeutics, Vol.23(2), pp.142-148
03/2018
DOI: 10.1177/1074248417732416
PMID: 28936878
Abstract
Recently, digoxin use has been found to associate with higher mortality. Yet, potential mechanisms by which digoxin use increases mortality remain unclear. Increased arrhythmogenicity from digoxin use is one possibility. Thus, we aimed to evaluate the relation between digoxin and shock events in patients with implantable cardioverter defibrillators (ICDs).
We performed a retrospective chart review of all patients with ICDs and at least 1 device interrogation at our institution between January 1, 2012, and January 1, 2015. We aimed to cover 1 year of interrogation period. Patients with heart failure, atrial fibrillation, or both were included in the analysis. Patients were divided into 2 groups based on digoxin use, defined as use of digoxin for any period of time during ICD interrogation period. Incidence of ICD shock events and electrical storms and hospitalizations were compared between the 2 groups.
The study included 202 patients. Of those, 55 patients were on digoxin and 147 were not on digoxin. Patients on digoxin were more likely to receive ICD shocks (odds ratio [OR] = 2.5, 95% confidence interval [95% CI] = 1.01-6.18, P = .04) and have increased risk of electrical storms ( P = .02). Moreover, total hospitalizations were higher in digoxin users ( P = .02). Multivariate logistic regression analysis also showed that digoxin use was an independent predictor of shock events (OR = 4.07, 95% CI = 1.43-11.58, P = .009).
Digoxin is associated with increased shock events and electrical storms in patients with ICDs; however, large randomized controlled studies are needed to confirm our findings.
Details
- Title: Subtitle
- Digoxin Is Associated With Increased Shock Events and Electrical Storms in Patients With Implantable Cardioverter Defibrillators
- Creators
- George S Mina - Louisiana State University Health Sciences Center ShreveportMadan Acharya - Louisiana State University Health Sciences Center ShreveportTaylor Shepherd - Louisiana State University Health Sciences Center ShreveportGeorge Gobrial - Louisiana State University Health Sciences Center ShreveportMichael Tekeste - Louisiana State University Health Sciences Center ShreveportHussam Watti - Louisiana State University Health Sciences Center ShreveportRuchi Bhandari - Louisiana State University Health Sciences Center ShreveportAditya Saini - Louisiana State University Health Sciences Center ShreveportPratap Reddy - Louisiana State University Health Sciences Center ShreveportPaari Dominic - Louisiana State University Health Sciences Center Shreveport
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular pharmacology and therapeutics, Vol.23(2), pp.142-148
- DOI
- 10.1177/1074248417732416
- PMID
- 28936878
- ISSN
- 1074-2484
- eISSN
- 1940-4034
- Language
- English
- Date published
- 03/2018
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984367238902771
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