Journal article
Diminished appetitive startle modulation following targeted inhibition of prefrontal cortex
Scientific reports, Vol.5(1), p.No. 8954
03/10/2015
DOI: 10.1038/srep08954
PMID: 25752944
Abstract
From an evolutionary perspective the startle eye-blink response forms an integral part of the human avoidance behavioral repertoire and is typically diminished by pleasant emotional states. In major depressive disorder (MDD) appetitive motivation is impaired, evident in a reduced interference of positive emotion with the startle response. Given the pivotal role of frontostriatal neurocircuitry in orchestrating appetitive motivation, we hypothesized that inhibitory transcranial magnetic stimulation (TMS) would reduce appetitive neuromodulation in a manner similar to MDD. Based on a pre-TMS functional MRI (fMRI) experiment we selected the left dorsolateral and dorsomedial prefrontal cortices as target regions for subsequent sham-controlled inhibitory theta-burst TMS (TBS) in 40 healthy male volunteers. Consistent with our hypothesis, between-group comparisons revealed a TBS-induced inhibition of appetitive neuromodulation, manifest in a diminished startle response suppression by hedonic stimuli. Collectively, our results suggest that functional integrity of left dorsolateral and dorsomedial prefrontal cortex is critical for mediating a pleasure-induced down-regulation of avoidance responses which may protect the brain from a depressogenic preponderance of defensive stress.
Details
- Title: Subtitle
- Diminished appetitive startle modulation following targeted inhibition of prefrontal cortex
- Creators
- René Hurlemann - University of BonnStephan Arndt - University of BonnThomas E. Schlaepfer - Johns Hopkins HospitalJuergen Reul - Beta Clinic, Bonn, GermanyWolfgang Maier - German Center for Neurodegenerative DiseasesDirk Scheele - University of Bonn
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.5(1), p.No. 8954
- DOI
- 10.1038/srep08954
- PMID
- 25752944
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Grant note
- Rheinische Friedrich-Wilhelms-Universität Bonn (http://data.elsevier.com/vocabulary/SciValFunders/501100008131) Ministry of Innovation, Science, Research and Technology of the State of North Rhine-Westphalia (http://data.elsevier.com/vocabulary/SciValFunders/100017331)
- Language
- English
- Date published
- 03/10/2015
- Academic Unit
- Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
- Record Identifier
- 9985132076902771
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