“Diminished” association between the serotonin transporter linked polymorphism (5HTTLPR) and body mass index in a large psychiatric sample

Gen Shinozaki; Yingying Kumar; Brooke H Rosen; James R Rundell; David A Mrazek; Simon Kung

doi:10.1016/j.jad.2013.06.021

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“Diminished” association between the serotonin transporter linked polymorphism (5HTTLPR) and body mass index in a large psychiatric sample

Journal article

Peer reviewed

“Diminished” association between the serotonin transporter linked polymorphism (5HTTLPR) and body mass index in a large psychiatric sample

Gen Shinozaki, Yingying Kumar, Brooke H Rosen, James R Rundell, David A Mrazek and Simon Kung

Journal of affective disorders, Vol.151(1), pp.397-400

10/2013

DOI: 10.1016/j.jad.2013.06.021

PMID: 23838390

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Abstract

The role of the promoter polymorphism (5HTTLPR) of the serotonin transporter gene (SLC6A4) in psychiatric illnesses has been studied extensively. Serotonergic function also regulates many central nervous system, including appetite and feeding behaviors. The 5HTTLPR short allele was found to be associated with increased body mass index and obesity risk among the general population. No data is available to support generalizability of such association among psychiatric population. We examined the relationship between BMI and the 5HTTLPR genotype in a large sample of 1831 psychiatric patients at Mayo Clinic, Rochester, Minnesota, using a retrospective chart review. Average BMI among groups with the short/short (28.29±7.27kg/m2), the short/long (28.07±6.45kg/m2) and the long/long (28.15±7.51kg/m2) genotypes of 5HTTLPR were not statistically different. This negative association persisted even with the sub-analysis of the Caucasians. However, we observed an increased rate of obesity among our psychiatric patient sample compared to the general population of Minnesota (36.6% versus 27.6%, p=0.0001 for males, 30.3% versus 24.4%, p=0.0001 for females). Also, sub-analysis showed female inpatients to have a significantly higher average BMI than outpatients (28.64±8.08kg/m2 versus 27.13±6.92kg/m2, p=0.026). This confirmed a significant association between mental health disorder and BMI. Retrospective study design with limited control for potential confounders. In this large sample of psychiatric patients we found no significant association between 5HTTLPR genotype and BMI, which is different from the case with general population reported in the literature.

Psychiatric patient

Body mass index

Serotonin transporter gene

5HTTLPR

SLC6A4

Details

Title: Subtitle: “Diminished” association between the serotonin transporter linked polymorphism (5HTTLPR) and body mass index in a large psychiatric sample
Creators: Gen Shinozaki - Sioux Falls VA Health Care System, Sioux Falls, SD, USA
Yingying Kumar - Mayo Medical School, Mayo Clinic, Rochester, MN, USA
Brooke H Rosen - Mayo Medical School, Mayo Clinic, Rochester, MN, USA
James R Rundell - Tamber, Plymouth, MN, USA
David A Mrazek - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
Simon Kung - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.151(1), pp.397-400
DOI: 10.1016/j.jad.2013.06.021
PMID: 23838390
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 10/2013
Academic Unit: Psychiatry; Anesthesia; Neurosurgery
Record Identifier: 9984003927602771

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