Journal article
Diode-pumped neodymium:yttrium aluminum garnet laser effects on the visceral pleura in an ex vivo porcine lung model
Interactive cardiovascular and thoracic surgery, Vol.28(3), pp.339-343
03/01/2019
DOI: 10.1093/icvts/ivy254
PMID: 30189016
Abstract
Resection of tumour spread on a very thin visceral pleura might be challenging, and collateral damage to the lung parenchyma might occur. We aimed to develop an operative technique, which might facilitate the parenchyma-sparing destruction of the visceral pleura. This experimental work investigated the effects of a neodymium:yttrium aluminum garnet (Nd:YAG) laser on the visceral pleura in an ex vivo porcine lung model.
We used a diode-pumped Nd:YAG laser (Limax® 120, KLS Martin, Tuttlingen, Germany) to investigate the effects on the visceral pleural in 20 porcine lungs. The laser was applied on a standardized length in 4 different settings: Group I (80 W, 6 s), Group II (80 W, 12 s), Group III (120 W, 6 s) and Group IV (120 W, 12 s). All specimens were analysed histologically.
The mean thickness of the visceral pleura was 81 ± 10 μm. Increasing power levels and longer application duration resulted in significantly enhanced laser destruction effects. The mean depths of the carbonization zone were 142 ± 42 µm, 378 ± 137 µm, 607 ± 155 µm and 1371 ± 271 μm for Groups I-IV, respectively (P < 0.001). The ratio of carbonization zone to pleural thickness was measured for each section (C/P ratio) to quantify the thermal effects. The corresponding C/P ratio for Groups I-IV were 1.72 ± 0.55, 4.98 ± 1.96, 7.11 ± 1.61 and 17.35 ± 4.35, respectively (P < 0.001).
Our study showed that increasing power levels and application duration of the laser lead to a significantly increased carbonization and destruction zones. Further in vivo human studies should evaluate the feasibility of laser application for a potential translational relevance for human use.
Details
- Title: Subtitle
- Diode-pumped neodymium:yttrium aluminum garnet laser effects on the visceral pleura in an ex vivo porcine lung model
- Creators
- Servet Bölükbas - Department of Thoracic Surgery, Kliniken Essen-Mitte Evang. Huyssens-Stiftung/Knappschafts-Krankenhaus, Essen, GermanyThorsten Greve - Department of Thoracic Surgery, Helios University Hospital Wuppertal, Wuppertal, GermanyChristian Biancosino - Department of Thoracic Surgery, Helios University Hospital Wuppertal, Wuppertal, GermanyMichael Eberlein - Division of Pulmonary, Department of Internal Medicine, Critical Care and Occupational Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USASarah Schumacher - Institute of Pathology, Helios University Hospital Wuppertal, Wuppertal, GermanyDaniel Gödde - Institute of Pathology, Helios University Hospital Wuppertal, Wuppertal, GermanyStephan Störkel - Institute of Pathology, Helios University Hospital Wuppertal, Wuppertal, GermanyBassam Redwan - Division of Thoracic Surgery and Lung Transplantation, Department of Cardiothoracic Surgery, University Hospital of Münster, Münster, Germany
- Resource Type
- Journal article
- Publication Details
- Interactive cardiovascular and thoracic surgery, Vol.28(3), pp.339-343
- DOI
- 10.1093/icvts/ivy254
- PMID
- 30189016
- ISSN
- 1569-9293
- eISSN
- 1569-9285
- Language
- English
- Date published
- 03/01/2019
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094383902771
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