Journal article
Direct Conversion of Benzylic and Allylic Alcohols to Phosphonates
Journal of organic chemistry, Vol.76(8), pp.2875-2879
04/15/2011
DOI: 10.1021/jo200137k
PMCID: PMC3204863
PMID: 21405073
Abstract
Benzyl phosphonate esters often serve as reagents in Horner−Wadsworth−Emmons reactions. In most cases, they can be prepared from benzylic alcohols via formation of the corresponding halide followed by an Arbuzov reaction. To identify a more direct synthesis of phosphonate esters, we have developed a one-flask procedure for conversion of benzylic and allylic alcohols to the corresponding phosphonates through treatment with triethyl phosphite and ZnI2.
Details
- Title: Subtitle
- Direct Conversion of Benzylic and Allylic Alcohols to Phosphonates
- Creators
- Rocky J BarneyRebekah M RichardsonDavid F Wiemer
- Resource Type
- Journal article
- Publication Details
- Journal of organic chemistry, Vol.76(8), pp.2875-2879
- DOI
- 10.1021/jo200137k
- PMID
- 21405073
- PMCID
- PMC3204863
- NLM abbreviation
- J Org Chem
- ISSN
- 0022-3263
- eISSN
- 1520-6904
- Publisher
- American Chemical Society
- Language
- English
- Date published
- 04/15/2011
- Academic Unit
- Neuroscience and Pharmacology; Chemistry
- Record Identifier
- 9983986095802771
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