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Direct Methenylation of 4-Alkylpyridines Using Eschenmoser’s Salt
Journal article   Peer reviewed

Direct Methenylation of 4-Alkylpyridines Using Eschenmoser’s Salt

Grant N. Shivers, Soe L. Tun, Shay L. McLean and Chris Pigge
Synlett, Vol.33(19), pp.1902-1906
08/02/2022
DOI: 10.1055/a-1916-5335

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Abstract

4-Alkylpyridines are converted to conjugated 1,1-disubstituted alkenyl pyridines (vinyl pyridines) upon treatment with excess ethyl chloroformate, triethylamine, and Eschenmoser’s salt. The reaction proceeds under mild conditions via alkylidene dihydropyridine intermediates
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